Document Detail

Myocardial hypertrophy induces carotid body hyperplasia.
MedLine Citation:
PMID:  20950315     Owner:  NLM     Status:  In-Data-Review    
The carotid bodies tend to enlarge after long-standing cardiopulmonary disease. Our objective was to investigate whether cardiac hypertrophy is associated with carotid body hyperplasia. Fifteen autopsy cases with combined left and right ventricular hypertrophy were examined and compared with two control groups (16 cases). The study involved a meticulous dissection of carotid bifurcations, thin serial sections, and morphometric analysis of carotid body volume and cell types (progenitor, dark, light, and sustentacular). There was a significant increase in sustentacular cells in all individuals with cardiac hypertrophy, which was not drug-induced, and accompanied by a similar increase in carotid body volume. Dark or light cell accumulation was detected focally and only in three instances. It appears that the generalized sustentacular cell hyperplasia is the result of long-standing hypoxia, while a superimposed focal prominence of dark or light cells may be proliferative or metaplastic in nature and attributed to short-term hypoxia.
Efthimios Sivridis; Pavlos Pavlidis; Aliki Fiska; Dimitra Pitsiava; Alexandra Giatromanolaki
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Publication Detail:
Type:  Journal Article     Date:  2010-10-15
Journal Detail:
Title:  Journal of forensic sciences     Volume:  56 Suppl 1     ISSN:  1556-4029     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S90-4     Citation Subset:  IM    
Copyright Information:
© 2010 American Academy of Forensic Sciences.
Department of Pathology, Democritus University of Thrace, University General Hospital of Alexandroupolis, Greece.
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