| Myocardial Fas and cytokine expression in end-stage heart failure: impact of LVAD support. | |
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MedLine Citation:
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PMID: 20443855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Left ventricular assist device (LVAD) support may facilitate myocardial recovery. We evaluated the impact of LVAD support on Fas expression in a cohort with end-stage heart failure. Myocardial gene expression was assessed pre- and post-LVAD by RNase protection assay and compared to control donor hearts. The expression of Fas is markedly elevated at the time of LVAD support and is tightly correlated with TNF expression. While interleukin (IL)-6 was significantly reduced by LVAD support, the impact of support on Fas was highly variable and tightly linked to tumor necrosis factor (TNF). The role of Fas in predicting recovery after LVAD support requires further investigation. |
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Authors:
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Maninder S Bedi; Rene J Alvarez; Toru Kubota; Richard Sheppard; Robert L Kormos; Michael P Siegenthaler; Arthur M Feldman; Charles F McTiernan; Dennis M McNamara |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Clinical and translational science Volume: 1 ISSN: 1752-8062 ISO Abbreviation: Clin Transl Sci Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2010-05-06 Completed Date: 2010-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101474067 Medline TA: Clin Transl Sci Country: United States |
Other Details:
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Languages: eng Pagination: 245-8 Citation Subset: IM |
Affiliation:
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Heart Failure/Transplantation Program, Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, CD95 / genetics* Cytokines / genetics* Female Gene Expression Regulation Heart Failure / immunology, therapy* Heart Ventricles Heart-Assist Devices* Humans Interleukin-6 / genetics Male Middle Aged Myocardium / metabolism* Tumor Necrosis Factor-alpha / genetics |
| Grant Support | |
ID/Acronym/Agency:
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HL66948/HL/NHLBI NIH HHS; K24 HL69912/HL/NHLBI NIH HHS; R01 HL75038/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/Cytokines; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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