Document Detail


Myocardial Fas and cytokine expression in end-stage heart failure: impact of LVAD support.
MedLine Citation:
PMID:  20443855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Left ventricular assist device (LVAD) support may facilitate myocardial recovery. We evaluated the impact of LVAD support on Fas expression in a cohort with end-stage heart failure. Myocardial gene expression was assessed pre- and post-LVAD by RNase protection assay and compared to control donor hearts. The expression of Fas is markedly elevated at the time of LVAD support and is tightly correlated with TNF expression. While interleukin (IL)-6 was significantly reduced by LVAD support, the impact of support on Fas was highly variable and tightly linked to tumor necrosis factor (TNF). The role of Fas in predicting recovery after LVAD support requires further investigation.
Authors:
Maninder S Bedi; Rene J Alvarez; Toru Kubota; Richard Sheppard; Robert L Kormos; Michael P Siegenthaler; Arthur M Feldman; Charles F McTiernan; Dennis M McNamara
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Clinical and translational science     Volume:  1     ISSN:  1752-8062     ISO Abbreviation:  Clin Transl Sci     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2010-05-06     Completed Date:  2010-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474067     Medline TA:  Clin Transl Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-8     Citation Subset:  IM    
Affiliation:
Heart Failure/Transplantation Program, Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antigens, CD95 / genetics*
Cytokines / genetics*
Female
Gene Expression Regulation
Heart Failure / immunology,  therapy*
Heart Ventricles
Heart-Assist Devices*
Humans
Interleukin-6 / genetics
Male
Middle Aged
Myocardium / metabolism*
Tumor Necrosis Factor-alpha / genetics
Grant Support
ID/Acronym/Agency:
HL66948/HL/NHLBI NIH HHS; K24 HL69912/HL/NHLBI NIH HHS; R01 HL75038/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD95; 0/Cytokines; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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