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Myocardial Blood Volume and Coronary Resistance During and After Coronary Angioplasty.
MedLine Citation:
PMID:  21217067     Owner:  NLM     Status:  Publisher    
Background: Animal experiments have shown that the coronary circulation is pressure-distensible, i.e. myocardial blood volume (MBV) increases with perfusion pressure. In humans, however, corresponding measurements are lacking so far. We sought to quantify parameters reflecting coronary distensibility such as MBV and coronary resistance (CR) during and after coronary angioplasty. Methods and results: Thirty patients with stable coronary artery disease underwent simultaneous coronary perfusion pressure assessment and myocardial contrast echocardiography (MCE) of 37 coronary arteries and their territories during and after angioplasty. MCE yielded MBV and myocardial blood flow (MBF, ml/min/g). Complete data set were obtained in 32 coronary arteries and their territories from 26 patients. During angioplasty, perfusion pressure, i.e. coronary occlusive pressure, and MBV varied between 9 - 57mmHg (26.9±11.9mmHg) and 1.2 - 14.5ml/100g (6.7±3.7ml/100g), respectively. After successful angioplasty, perfusion pressure and MBV increased significantly (p<0.001 for both) and varied between 64 - 118mmHg (93.5±12.8mmHg) and 3.7 - 17.3ml/100g (9.8±3.4ml/100g), respectively. Mean MBF increased from 31±20ml/min/100g during coronary occlusion reflecting collateral flow to 121±33ml/min/100g (p<0.01) while mean CR, i.e. the ratio of perfusion pressure and MBF, decreased by 20% (p<0.001). Conclusions: The human coronary circulation is pressure-distensible. Myocardial contrast echocardiography allows for the quantification of coronary resistance and myocardial blood volume in humans.
Andreas Indermühle; Rolf Vogel; Pascal Meier; Rainer Zbinden; Christian Seiler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-7
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Bern University Hospital.
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