| Myocardial 18F-FDG uptake after exercise-induced myocardial ischemia in patients with coronary artery disease. | |
| | |
MedLine Citation:
|
PMID: 18997035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have recently demonstrated the potential of (18)F-FDG as an imaging marker of myocardial ischemia if injected at peak exercise. However, how long increased (18)F-FDG uptake can be observed after an episode of exercise-induced myocardial ischemia is not known. We performed the current study to determine whether increased regional myocardial (18)F-FDG uptake at exercise in patients with coronary artery disease (CAD) persists on rest imaging (24 h later), after an episode of exercise-induced myocardial ischemia. METHODS: Twenty-four patients with suspected CAD underwent exercise (99m)Tc-sestamibi and (18)F-FDG imaging. Repeated (18)F-FDG imaging was performed 24 h after exercise imaging, after an injection of a second dose of (18)F-FDG at rest in 20 patients. Perfusion imaging with (99m)Tc-sestamibi was simultaneously performed with (18)F-FDG imaging. All patients underwent coronary angiography. RESULTS: Eighteen patients had greater than or equal to 70% luminal narrowing of 1 or more coronary vessels. Fifteen patients (83%) showed increased regional (18)F-FDG uptake on exercise imaging, but only 11 patients (61%) had perfusion abnormalities. Of these 15 patients with increased regional (18)F-FDG uptake on exercise imaging, 8 (53%) had no discernible (18)F-FDG uptake, 5 (33%) had decreased (18)F-FDG uptake, and only 2 (13%) had persistent (18)F-FDG uptake on rest (18)F-FDG images. The summed (18)F-FDG uptake score significantly decreased, from 14.4 +/- 10.3 at exercise to 6.7 +/- 9.2 at rest (P = 0.01). Patients with persistent (18)F-FDG uptake at rest had more (18)F-FDG uptake and lower peak rate-pressure product at exercise, compared with patients with no residual (18)F-FDG uptake at rest. CONCLUSION: Exercise-induced regional myocardial (18)F-FDG uptake is highly specific and sensitive for exercise-induced myocardial ischemia. Regional myocardial (18)F-FDG uptake may persist 24 h after an episode of exercise-induced myocardial ischemia in some patients. |
| | |
Authors:
|
Ke-Fei Dou; Min-Fu Yang; Yue-Jin Yang; Diwakar Jain; Zuo-Xiang He |
Related Documents
:
|
11175065 - Transnasal transesophageal stress echocardiography. 9568455 - Dipyridamole stress thallium-201 perfusion abnormalities in patients with hypertrophic ... 6821615 - Effect of beta adrenergic blockade on thallium-201 myocardial perfusion imaging. 7722125 - Adenosine combined with dynamic exercise for myocardial perfusion imaging. 860695 - Exertional hypotension and postexertional ventricular fibrillation in stress testing. 738305 - Some influences of the contractile element on the visco-elastic properties of bladder w... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-07 |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 49 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-28 Completed Date: 2009-02-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1986-91 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Coronary Artery Disease
/
etiology,
metabolism*,
radionuclide imaging* Exercise Test Female Fluorodeoxyglucose F18 / diagnostic use*, pharmacokinetics* Humans Male Metabolic Clearance Rate Middle Aged Myocardial Ischemia / etiology, metabolism*, radionuclide imaging* Positron-Emission Tomography / methods Radiopharmaceuticals / diagnostic use, pharmacokinetics Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
|
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
Comment In:
|
J Nucl Med. 2008 Dec;49(12):1909-11
[PMID:
18997055
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in cerebral glucose metabolism in patients with Parkinson disease with dementia after cholin...
Next Document: Kinetic modeling of 3'-deoxy-3'-18F-fluorothymidine for quantitative cell proliferation imaging in s...