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Myocardial (123) I-metaiodobenzylguanidine Washout and Heart Rate Variability in Asymptomatic Subjects.
MedLine Citation:
PMID:  22276623     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Myocardial (123) I-metaiodobenzylguanidine (MIBG) kinetics reflect the integrity and function of cardiac presynaptic sympathetic nerve terminals. Heart rate variability (HRV) is an indicator of cardiac sympatho-vagal balance. However, the function of cardiac sympathetic nerve terminals as a modulator of HRV in asymptomatic subjects has remained elusive. In addition, the physiological background for different components of HRV is not fully established. Methods: We evaluated the relationship between myocardial MIBG washout and HRV in 30 asymptomatic subjects with familial risk of coronary artery disease (CAD). Early and delayed myocardial MIBG uptakes as well as MIBG washout between these two scans were assessed. Myocardial perfusion at rest and during bicycle exercise was evaluated with (99m) Tc-sestamibi (MIBI). HRV was measured from 24-hour ambulatory ECG recordings. Results: Myocardial MIBG washout averaged 40 ± 8%. The mean heart rate at rest was 76 ± 14 beats/min. Standard deviation of all normal RR intervals (SDNN) was 94 ± 22 ms and very low frequency (VLF) was 1625 ± 958 ms(2) on average. Myocardial MIBG washout correlated inversely with SDNN (r =-0.390; P < 0.05) and with VLF (r =-0.459; P < 0.01) component of HRV but not with heart rate at rest (r = 0.207, P = ns). All subjects had normal myocardial perfusion at rest and during exercise. Conclusions: Increased cardiac presynaptic sympathetic nervous activity was related to reduced HRV in subjects with the risk of CAD but without evidence of myocardial ischemia or previous myocardial infarction. In addition, we found that VLF component of HRV includes information about sympathetic neural modulation of the heart rate. Ann Noninvasive Electrocardiol 2012;17(1):8-13.
Authors:
Sakari Simula; Esko Vanninen; Antti Hedman; Seppo Lehto; Jyrki Kuikka; Juha Hartikainen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  17     ISSN:  1542-474X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-13     Citation Subset:  IM    
Copyright Information:
© 2012, Wiley Periodicals, Inc.
Affiliation:
Department of Neurology, Mikkeli Central Hospital, Mikkeli Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland Heart Center, Kuopio University Hospital and University of Eastern Finland Department of Medicine, Kuopio University Hospital and University of Eastern Finland Niuvanniemi Hospital, Kuopio, Finland.
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