| Myocardial 11C-diacylglycerol accumulation and left ventricular remodeling in patients after myocardial infarction. | |
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MedLine Citation:
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PMID: 15809475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Left ventricular (LV) remodeling after myocardial infarction (MI) is a maladaptive process that increases the risk of heart failure and death. The myocardial phosphoinositide cycle, which is located downstream from several neurohumoral factors, plays a crucial role in LV remodeling. Our animal studies demonstrated that 1-[1-11C]butyryl-2-palmitoyl-rac-glycerol (11C-DAG) can be used to visualize regions with an activated phosphoinositide cycle. Therefore, we examined whether myocardial 11C-DAG accumulation assessed by PET is relevant to LV enlargement and systolic dysfunction in post-MI patients. METHODS: We performed PET with 11C-DAG in 13 post-anteroseptal MI patients and 4 healthy volunteers. We placed regions of interest on the noninfarcted myocardium and calculated the myocardium-to-left atrial (LA) chamber ratio of 11C-DAG accumulation. RESULTS: The myocardium-to-LA chamber ratio of 11C-DAG was significantly higher in the post-MI patients (mean +/- SD, 1.73 +/- 0.35) compared with that of the healthy volunteers (mean +/- SD, 1.25 +/- 0.13; P < 0.05). In the post-MI patients, the myocardium-to-LA chamber ratio of (11)C-DAG was significantly correlated with the LV end-diastolic volume index (r = 0.79, P < 0.01) and the plasma concentration of brain natriuretic peptide (r = 0.85, P < 0.001) and negatively correlated with the LV ejection fraction (r = -0.69, P < 0.01). CONCLUSION: These findings suggest that the myocardial 11C-DAG accumulation assessed by PET is relevant to LV enlargement, LV systolic dysfunction, and humoral activation in post-MI patients. This new imaging strategy based on intracellular signaling may contribute to the assessment and treatment of post-MI patients. |
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Authors:
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Hiroki Otani; Yutaka Kagaya; Yoshio Imahori; Satoshi Yasuda; Ryo Fujii; Masanobu Chida; Shigeto Namiuchi; Morihiko Takeda; Masahito Sakuma; Jun Watanabe; Tatsuo Ido; Hiroshi Nonogi; Kunio Shirato |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 46 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-05 Completed Date: 2005-06-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 553-9 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Glycerides / diagnostic use*, pharmacokinetics* Humans Male Middle Aged Myocardial Infarction / complications, metabolism*, radionuclide imaging* Radiopharmaceuticals / diagnostic use, pharmacokinetics Reproducibility of Results Sensitivity and Specificity Statistics as Topic Ventricular Dysfunction, Left / etiology, metabolism*, radionuclide imaging* Ventricular Remodeling / physiology* |
| Chemical | |
Reg. No./Substance:
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0/1-butyryl-2-palmitoyl-rac-glycerol; 0/Glycerides; 0/Radiopharmaceuticals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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