Document Detail


Myoblasts in pattern formation and gene therapy.
MedLine Citation:
PMID:  8379006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The tissues of a multicellular animal are composed of diverse cell types arranged in a precisely organized pattern. Features unique to muscle allow an analysis of pattern formation and maintenance in mammals. The progeny of single cells can be taken full cycle from the animal to the culture dish and back to the animal where they fuse into mature myofibers of the host. These features not only facilitate the use of genetically engineered myoblasts in studies of pattern formation, but also in cell-mediated gene therapy: a novel mode of drug delivery for the treatment of muscle and nonmuscle diseases such as hemophilia, cardiac disease and cancer.
Authors:
H M Blau; J Dhawan; G K Pavlath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Trends in genetics : TIG     Volume:  9     ISSN:  0168-9525     ISO Abbreviation:  Trends Genet.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-10-19     Completed Date:  1993-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8507085     Medline TA:  Trends Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  269-74     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Stanford University School of Medicine, CA 94305-5332.
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MeSH Terms
Descriptor/Qualifier:
Animals
Gene Therapy*
Genetic Vectors
Humans
Muscles / cytology*,  metabolism
Recombinant Proteins / administration & dosage
Chemical
Reg. No./Substance:
0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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