| Myoblast fusion: lessons from flies and mice. | |
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MedLine Citation:
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PMID: 22274696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscle function, as it supports the formation of extended sarcomeric arrays, or myofibrils, within a large volume of cytoplasm. Principles learned from the study of myoblast fusion not only enhance our understanding of myogenesis, but also contribute to our perspectives on membrane fusion and cell-cell fusion in a wide array of model organisms and experimental systems. Recent studies have advanced our views of the cell biological processes and crucial proteins that drive myoblast fusion. Here, we provide an overview of myoblast fusion in three model systems that have contributed much to our understanding of these events: the Drosophila embryo; developing and regenerating mouse muscle; and cultured rodent muscle cells. |
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Authors:
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Susan M Abmayr; Grace K Pavlath |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 139 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-25 Completed Date: 2012-03-16 Revised Date: 2012-04-19 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 641-56 Citation Subset: IM |
Affiliation:
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Stowers Institute for Medical Research, Kansas City, MO 64110, USA. sma@stowers.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion / physiology Cell Communication / physiology Cell Differentiation / physiology Cell Fusion* Cell Movement / physiology Cell Surface Extensions / metabolism Cells, Cultured Cytoskeletal Proteins / metabolism Cytoskeleton / metabolism Drosophila / anatomy & histology, embryology* Giant Cells / cytology, physiology Membrane Fusion / physiology Mice / anatomy & histology, embryology* Morphogenesis / physiology Muscle, Skeletal / cytology, physiology Myoblasts / cytology, physiology* Regeneration / physiology Signal Transduction / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 AR047314-10/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytoskeletal Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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