| Myoblast fusion in Drosophila. | |
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MedLine Citation:
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PMID: 18979239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myogenic differentiation in Drosophila melanogaster, as in many other organisms, involves the generation of multinucleate muscle fibers through the fusion of myoblasts. Prior to fusion, the myoblasts become specified as one of two distinct cell types. They then become competent to fuse and express genes associated with cell recognition and adhesion. Initially, cell-type- specific adhesion molecules mediate recognition and fusion between these two distinct populations of myoblasts. Intracellular proteins that are essential for the fusion process are then recruited to points of cell-cell contact at the membrane, where the cell surface molecules have become localized. Many of these cytosolic proteins contribute to reorganization of the cytoskeleton through activation of small guanosine triphosphatases and recruitment of actin nucleating proteins. Following the initial fusion event, the ultimate size of the syncytia is achieved through multiple rounds of fusion between the developing syncytia and mononucleate myoblasts. Ultrastructural changes associated with cell fusion include recruitment of electron-dense vesicles to points of cell-cell contact, resolution of these vesicles into fusion plaques, fusion pore formation, and membrane vesiculation. This chapter reviews our current understanding of the genes, pathways, and ultrastructural events associated with fusion in the Drosophila embryo, giving rise to multinucleate syncytia that will be used throughout larval life. |
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Authors:
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Susan M Abmayr; Shufei Zhuang; Erika R Geisbrecht |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 475 ISSN: 1064-3745 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-11-03 Completed Date: 2008-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 75-97 Citation Subset: IM |
Affiliation:
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The Stowers Institute for Medical Research, Kansas City, MO, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion Cell Fusion Cell Movement Drosophila Proteins / metabolism Drosophila melanogaster / cytology*, ultrastructure Myoblasts / cytology*, ultrastructure |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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