| Myo-inositol deficiency in gerbils: comparative study of the intestinal lipodystrophy in Meriones unguiculatus and Meriones libycus. | |
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MedLine Citation:
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PMID: 6155458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Like Mongolian gerbils (Meriones unguiculatus), Meriones libycus develop an intestinal lipodystrophy due to myo-inositol deficiency. Fat accumulation was observed in the intestine of both species when a myo-inositol-deficient diet containing coconut oil was fed to female gerbils. It began in the duodenum and gradually extended to the entire small intestine. Starvation partially removed the accumulated fats. The efficiency of fat absorption was not affected. Most of the accumulated fats were lauric acid-rich triglyceride with the fatty acid composition reflecting the pattern of the intestinal lymph triglyceride during normal transport of absorbed coconut oil. The ratio of oleic acid to linoleic acid in various intestinal lipids was increased. A marked decrease in all plasma lipid and lipoprotein concentrations, including chylomicron, was also observed. It is assumed that the intestinal fat accumulation resulted from a defect in lymphatic transport of dietary fats. |
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Authors:
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S H Chu; D M Hegsted |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of nutrition Volume: 110 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1980 Jun |
Date Detail:
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Created Date: 1980-08-28 Completed Date: 1980-08-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1209-16 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cocos Dietary Fats Female Inositol / deficiency* Intestines / metabolism Lipid Metabolism* Phospholipids / metabolism Species Specificity Starvation / metabolism Triglycerides / metabolism Whipple Disease / etiology* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Phospholipids; 0/Triglycerides; 6917-35-7/Inositol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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