Document Detail


Myo- and hepatotoxic effects of cultivated mushrooms in mice.
MedLine Citation:
PMID:  18976689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mushrooms are currently examined for their potential as functional foods. At the same time, novel types of mushroom intoxications, such as rhabdomyolysis after prolonged consumption, have been described in edible species. The aim of the present study was to perform an acute toxicity test to establish if the most commonly cultivated species would have myo- or hepatotoxic effects. Mice (n=6/group) were exposed to 3, 6 or 9 g Agaricus bisporus, Lentinus edodes or Pleurotus ostreatus kg body mass(-1) d(-1) for 5 d with 6 controls. Food and water intakes, plasma clinical chemistry and liver and muscle histology were evaluated. While A. bisporus caused significantly increased plasma bilirubin concentrations, L. edodes elicited also increased plasma creatine kinase activities at 9 g kg(-1) d(-1). P. ostreatus decreased dramatically the food intake but increased the water intake and caused significantly increased plasma alanine aminotransferase activities at 9 g kg(-1) d(-1). While there were no pathological findings in the histological samples, it seems that the doses and time periods required for the potential benefits of mushroom consumption to appear are similar to those causing undesirable effects. This should be taken into consideration if mushrooms are to be used as functional foods.
Authors:
Petteri Nieminen; Vesa Kärjä; Anne-Mari Mustonen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-14
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  47     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-12     Completed Date:  2009-03-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  70-4     Citation Subset:  IM    
Affiliation:
University of Joensuu, Faculty of Biosciences, P.O. Box 111, FI-80101 Joensuu, Finland. pniemine@cc.joensuu.fi
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MeSH Terms
Descriptor/Qualifier:
Agaricus*
Animals
Body Weight
Diet
Drug-Induced Liver Injury*
Female
Mice
Muscular Diseases*
Pleurotus*
Shiitake Mushrooms*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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