Document Detail

Myeloperoxidase may contribute to the no-reflow phenomenon in patients with acute myocardial infarction.
MedLine Citation:
PMID:  19138806     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The no-reflow phenomenon is a deteriorating factor for prognosis of acute myocardial infarction (AMI). Leukocyte enzymes may be involved in developing the no-reflow phenomenon. The aim of this study was to clarify the association of myeloperoxidase, a leukocyte enzyme, with the no-reflow phenomenon in patients with AMI after percutaneous coronary inetervention (PCI). METHODS: We enrolled 50 patients with AMI whose infarct-related coronary arteries were rescued by thrombectomy devices. Blood samples were collected from peripheral vein (PV), ostium and culprit lesion of infarct-related coronary artery. Myeloperoxidase, elastase and interleukin (IL)-8 were measured by ELISA. Antegrade blood flow in the infarct-related coronary artery and myocardial perfusion were evaluated according to the corrected TIMI frame counts (cTFC) and the myocardial blush grade (MBG). RESULTS: Plasma myeloperoxidase and IL-8 levels at the ostium and the culprit lesion of infarct-related coronary artery were significantly greater than those in PV. No-reflow was found in 10 patients (20%). Plasma levels of myeloperoxidase at the culprit lesion of infarct-related coronary artery were significantly greater in the patients with no-reflow than those without no-reflow. Plasma myeloperoxidase levels at the culprit lesion of infarct-related coronary artery positively correlated with the cTFC. Also, plasma myeloperoxidase levels were significantly higher in the patients with MBG 0-1 than those with MBG 2-3. CONCLUSIONS: The present findings indicate that local myeloperoxidase levels in the culprit coronary artery may contribute to the no-reflow phenomenon in the patients with AMI.
Hiroshi Funayama; San-e Ishikawa; Yoshitaka Sugawara; Norifumi Kubo; Shin-ichi Momomura; Masanobu Kawakami
Related Documents :
20846606 - Impact of systolic and diastolic deformation indexes assessed by strain-encoded imaging...
19562036 - Rosiglitazone and myocardial infarction in patients previously prescribed metformin.
8504576 - Characteristics of reactive electropermeable points on the auricles of coronary heart d...
19138806 - Myeloperoxidase may contribute to the no-reflow phenomenon in patients with acute myoca...
3995996 - Effect of increased levels of free fatty acids on the size of the ischaemic area.
25285656 - Quantification of left ventricular torsion and diastolic recoil using cardiovascular ma...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-12
Journal Detail:
Title:  International journal of cardiology     Volume:  139     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  IM    
Copyright Information:
Copyright 2008 Elsevier Ireland Ltd. All rights reserved.
Department of Medicine, Jichi Medical University Saitama Medical Center, 1-847 Amanuma Omiya-ku, Saitama, Saitama 330-8503 Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Angiography
Coronary Circulation / physiology*
Interleukin-8 / blood
Middle Aged
Myocardial Infarction / metabolism*,  radiography,  therapy*
Pancreatic Elastase / blood
Peroxidase / blood*
Treatment Failure
Reg. No./Substance:
0/Interleukin-8; EC; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Retrograde recanalization of an in-stent ostial chronically occluded right coronary artery.
Next Document:  Early and long-term survival after aortic valve replacement in septuagenarians and octogenarians wit...