Document Detail


Myeloperoxidase may contribute to the no-reflow phenomenon in patients with acute myocardial infarction.
MedLine Citation:
PMID:  19138806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The no-reflow phenomenon is a deteriorating factor for prognosis of acute myocardial infarction (AMI). Leukocyte enzymes may be involved in developing the no-reflow phenomenon. The aim of this study was to clarify the association of myeloperoxidase, a leukocyte enzyme, with the no-reflow phenomenon in patients with AMI after percutaneous coronary inetervention (PCI). METHODS: We enrolled 50 patients with AMI whose infarct-related coronary arteries were rescued by thrombectomy devices. Blood samples were collected from peripheral vein (PV), ostium and culprit lesion of infarct-related coronary artery. Myeloperoxidase, elastase and interleukin (IL)-8 were measured by ELISA. Antegrade blood flow in the infarct-related coronary artery and myocardial perfusion were evaluated according to the corrected TIMI frame counts (cTFC) and the myocardial blush grade (MBG). RESULTS: Plasma myeloperoxidase and IL-8 levels at the ostium and the culprit lesion of infarct-related coronary artery were significantly greater than those in PV. No-reflow was found in 10 patients (20%). Plasma levels of myeloperoxidase at the culprit lesion of infarct-related coronary artery were significantly greater in the patients with no-reflow than those without no-reflow. Plasma myeloperoxidase levels at the culprit lesion of infarct-related coronary artery positively correlated with the cTFC. Also, plasma myeloperoxidase levels were significantly higher in the patients with MBG 0-1 than those with MBG 2-3. CONCLUSIONS: The present findings indicate that local myeloperoxidase levels in the culprit coronary artery may contribute to the no-reflow phenomenon in the patients with AMI.
Authors:
Hiroshi Funayama; San-e Ishikawa; Yoshitaka Sugawara; Norifumi Kubo; Shin-ichi Momomura; Masanobu Kawakami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-12
Journal Detail:
Title:  International journal of cardiology     Volume:  139     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  IM    
Copyright Information:
Copyright 2008 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Medicine, Jichi Medical University Saitama Medical Center, 1-847 Amanuma Omiya-ku, Saitama, Saitama 330-8503 Japan. funahiro@omiya.jichi.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Angiography
Coronary Circulation / physiology*
Female
Humans
Interleukin-8 / blood
Male
Middle Aged
Myocardial Infarction / metabolism*,  radiography,  therapy*
Pancreatic Elastase / blood
Peroxidase / blood*
Treatment Failure
Chemical
Reg. No./Substance:
0/Interleukin-8; EC 1.11.1.7/Peroxidase; EC 3.4.21.36/Pancreatic Elastase

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