Document Detail


Myeloperoxidase expression by histiocytes in Kikuchi's and Kikuchi-like lymphadenopathy.
MedLine Citation:
PMID:  11549584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty-five examples of Kikuchi's lymphadenitis (KL), 5 Kikuchi-like lupus erythematosus lymphadenopathies, 25 nonnecrotizing lymphadenitidies (5 toxoplasmic, 5 sarcoid-like, 6 dermatopathic, 4 suppurative, 3 tubercular, 2 with sinus histiocytosis), 4 examples of hyaline-vascular Castleman disease (CD), 2 plasmacytoid monocyte tumors (PM-Ts), and 61 accessory cell neoplasms were studied by a panel of antibodies, including the PG-M1 (against a macrophage-restricted CD68 epitope) and a polyclonal anti-myeloperoxidase (MPO). In KL and Kikuchi-like lupus erythematosus lymphadenopathies, 25 to 75% of CD68(+) histiocytes co-expressed MPO. This did not occur in nonnecrotizing lymphadenitidies and accessory cell neoplasms. MPO(+)/CD68(+) elements corresponded to nonphagocytosing mononuclear cells and some crescentic macrophages and phagocytosing histiocytes. Typical PMs were MPO(-)/CD68(+) in all cases, including CD and PM-T. Our observations suggest that in KL and KL-like lymphadenopathies: 1) MPO(+)/CD68(+) blood monocytes might be attracted into tissues because of the lack or paucity of granulocytes and the need of MPO for oxidative processes; 2) PMs are more likely to be involved in the cytotoxic immune reaction than in phagocytic phenomena; 3) the peculiar phenotype of the histiocytic component can be usefully used for the differentiation from malignant lymphoma and PM-T.
Authors:
S A Pileri; F Facchetti; S Ascani; E Sabattini; S Poggi; M Piccioli; D Rondelli; F Vergoni; P L Zinzani; P P Piccaluga; B Falini; P G Isaacson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of pathology     Volume:  159     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-10     Completed Date:  2001-10-11     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  915-24     Citation Subset:  AIM; IM    
Affiliation:
Pathology and Clinical Units, Institute of Hematology and Clinical Oncology L. & A. Seràgnoli, Bologna University, Bologna, Italy. pileri@almadns.unibo.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cell Separation
Female
Flow Cytometry
Histiocytes / metabolism*,  pathology
Histiocytic Necrotizing Lymphadenitis / enzymology*,  pathology
Humans
Lymphatic Diseases / enzymology*,  pathology
Lymphoid Tissue / pathology
Male
Middle Aged
Peroxidase / metabolism*
Reference Values
Chemical
Reg. No./Substance:
EC 1.11.1.7/Peroxidase
Comments/Corrections

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