| Myeloperoxidase-deficient polymorphonuclear leucocytes. (I) Incidence in untreated myeloid leukaemia, lymphoid leukaemia and normal humans. | |
| | |
MedLine Citation:
|
PMID: 6304866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Neutrophil myeloperoxidase (MPO) activity was analysed semi-quantitatively both by (i) MPO-scoring of polymorphonuclear leucocytes (PMN) and (ii) counting the MPO-deficient PMN (PMN lacking MPO) in 164 subjects (60 cases of leukaemia and 104 normal humans). The scoring method showed that 10 out of 21 (48%) cases of acute myeloid leukaemia (AML), 2 out of 10 (20%) cases of chronic myeloid leukaemia (CML), 0 out of 29 cases of lymphoid leukaemia (ALL + CLL), and 1 out of 104 normal humans had decreased MPO scores. These figures correlated well with the more simple counting of PMN lacking MPO in the same groups: 8 out of 21 (37%) cases of AML, 6 out of 10 (60%) cases of CML and 0 out of 29 cases of lymphoid leukaemia showing more than 4% PMN lacking MPO. In cases of otherwise unclassifiable acute leukaemia, a decreased MPO score and an increased number of MPO-deficient PMN suggests the diagnosis of AML and not ALL. Counting the number of PMN lacking MPO was found to be a time-saving and even more reliable method than the semiquantitative scoring of MPO activity in PMN. |
| | |
Authors:
|
K Bendix-Hansen; H Kaspersen Nielsen |
Related Documents
:
|
8139286 - Immunophenotyping of acute lymphoblastic leukaemia in madras, india. 8826896 - Acute myeloid leukaemia with t(8;16)(p11;p13) in a child after intrauterine x-ray expos... 6585236 - Hyperleukocytosis and leukostasis: common features of childhood chronic myelogenous leu... 8177146 - Juvenile xanthogranuloma and acute leukemia: a case report. 16086956 - The value of visual evoked potentials in the evaluation of periorbital hemangiomas. 15909696 - Foreign accent syndrome: anatomic, pathophysiologic and psychosocial considerations. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Scandinavian journal of haematology Volume: 30 ISSN: 0036-553X ISO Abbreviation: Scand J Haematol Publication Date: 1983 May |
Date Detail:
|
Created Date: 1983-07-29 Completed Date: 1983-07-29 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404507 Medline TA: Scand J Haematol Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 415-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Female Humans Leukemia / blood, enzymology* Leukemia, Lymphoid / enzymology Leukemia, Myeloid / enzymology Leukemia, Myeloid, Acute / enzymology Male Neutrophils / enzymology* Peroxidase / deficiency*, metabolism Peroxidases / deficiency* |
| Chemical | |
Reg. No./Substance:
|
EC 1.11.1.-/Peroxidases; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nuclear fluorescing particles (F-bodies) in lymphocytes in chronic lymphocytic leukaemia.
Next Document: Cyclic nucleotides and catecholamines in rheumatoid arthritis.