| Myeloperoxidase binds to vascular endothelial cells, is recognized by ANCA and can enhance complement dependent cytotoxicity. | |
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MedLine Citation:
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PMID: 8296599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myeloperoxidase (MPO) and proteinase-3 (Pr-3) can bind to vascular endothelial cells (EC) and are available for recognition by autoantibodies present in P-ANCA or C-ANCA containing sera, respectively. The bound MPO also retains its enzymic functions and effectively interacts with hydrogen peroxide to mediate detachment of endothelial cells from their substratum. EC bound MPO-anti-MPO complexes can contribute to the complement-dependent EC injury demonstrated by some P-ANCA sera. |
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Authors:
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C O Savage; G Gaskin; C D Pusey; J D Pearson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 336 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1993 |
Date Detail:
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Created Date: 1994-03-03 Completed Date: 1994-03-03 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 121-3 Citation Subset: IM |
Affiliation:
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Vascular Biology Section, Clinical Research Centre, Harrow, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Antineutrophil Cytoplasmic Autoantibodies / immunology* Cells, Cultured Complement System Proteins / immunology Cytotoxicity, Immunologic* Endothelium, Vascular / drug effects, enzymology*, immunology Humans Hydrogen Peroxide / pharmacology Immunoglobulin G / pharmacology Peroxidase / immunology, pharmacology, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic; 0/Autoantibodies; 0/Immunoglobulin G; 7722-84-1/Hydrogen Peroxide; 9007-36-7/Complement System Proteins; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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