| Myeloperoxidase activity is increased in gingival crevicular fluid and whole saliva after fixed orthodontic appliance activation. | |
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MedLine Citation:
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PMID: 21055602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Orthodontic tooth movement uses mechanical forces that result in inflammation in the first days. Myeloperoxidase (MPO) is an enzyme found in polymorphonuclear neutrophil (PMN) granules, and it is used to estimate the number of PMN granules in tissues. So far, MPO has not been used to study the inflammatory alterations after the application of orthodontic tooth movement forces. The aim of this study was to determine MPO activity in the gingival crevicular fluid (GCF) and saliva (whole stimulated saliva) of orthodontic patients at different time points after fixed appliance activation. METHODS: MPO was determined in the GCF and collected by means of periopaper from the saliva of 14 patients with orthodontic fixed appliances. GCF and saliva samples were collected at baseline, 2 hours, and 7 and 14 days after application of the orthodontic force. RESULTS: Mean MPO activity was increased in both the GCF and saliva of orthodontic patients at 2 hours after appliance activation (P <0.02 for all comparisons). At 2 hours, PMN infiltration into the periodontal ligament from the orthodontic force probably results in the increased MPO level observed at this time point. CONCLUSIONS: MPO might be a good marker to assess inflammation in orthodontic movement; it deserves further studies in orthodontic therapy. |
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Authors:
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Andrea M Marcaccini; Patricia A F Amato; Fernanda V Leão; Raquel F Gerlach; Jose T L Ferreira |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics Volume: 138 ISSN: 1097-6752 ISO Abbreviation: Am J Orthod Dentofacial Orthop Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2010-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610224 Medline TA: Am J Orthod Dentofacial Orthop Country: United States |
Other Details:
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Languages: eng Pagination: 613-6 Citation Subset: D; IM |
Copyright Information:
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Copyright © 2010 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Morphology, Stomatology and Physiology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. amarcaccini@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Female Follow-Up Studies Gingival Crevicular Fluid / enzymology* Humans Male Neutrophil Infiltration / physiology Neutrophils / enzymology Orthodontic Wires* Periodontal Ligament / pathology Peroxidase / analysis* Saliva / enzymology* Stress, Mechanical Tooth Movement / instrumentation |
| Chemical | |
Reg. No./Substance:
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EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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