Document Detail

Myelomatous pleural effusion: clinical course and immunologic characterization of the pleural fluid cells.
MedLine Citation:
PMID:  384784     Owner:  NLM     Status:  MEDLINE    
Multiple myeloma is a disease that infrequently involves nonreticuloendothelial tissues and rarely causes pleural effusion. A 59-year-old woman had pleural effusion as the major manifestation of multiple myeloma. Light microscopy of her pleural fluid with Wright stained preparations showed all cells to be bizarre and often multinucleated plasmacytes. Electron microscopy confirmed these results. Intracellular immunofluorescence revealed IgG-kappa immunoglobulin (Ig) in greater than 90% of these cells. Surface immunofluorescence using anti-Ig sera was seen on less than 5% of the pleural fluid cells. 3H leucine incorporation into Ig in vitro was measured for these cells, and secretory curves were obtained that have the typical secretory kinetics of bone marrow plasmacytes. This demonstrates that such cells are viable and are able to synthesize and release immunoglobulin. Treatment of our patient with prednisone, melphalan, and cyclophosphamide resulted in symptomatic improvement and complete resolution of her pleural effusion. Pleural effusion is an unusual but important complication of multiple myeloma and does not necessarily carry the grave prognosis implied in previous reports.
D C Scullin; H J Cohen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  6     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1979  
Date Detail:
Created Date:  1979-11-28     Completed Date:  1979-11-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-73     Citation Subset:  IM    
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MeSH Terms
Fluorescent Antibody Technique
Immunoglobulins / biosynthesis
Middle Aged
Multiple Myeloma / immunology*
Plasma Cells / immunology*,  ultrastructure
Pleural Effusion / immunology*
Reg. No./Substance:

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