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Myelomatous pleural effusion as an initial sign of multiple myeloma-a case report and review of literature.
MedLine Citation:
PMID:  25093103     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: Discuss and improve the understanding of the clinical characters and diagnostic methods of myelomatous pleurisy, particularly of the patients with pleural effusion as an initial manifestation.
BACKGROUND: A 53-year-old male, who had been misdiagnosed as tuberculous pleurisy in a local hospital, was diagnosed as multiple myeloma (MM) with pleural infiltration. We reviewed the literature on clinical manifestations, serum and pleural effusion characters, treatment and diagnostic options of this exceptionally rare presentation of MM.
METHODS: We conducted a search of the published medical literature since 2000 in MEDLINE and PubMed using search criteria [("pleural effusion" and "MM") or "myelomatous pleural effusions"]. The search led to 64 case reports, and 16 cases with pleural effusion as an initial manifestation were included in this review. We have also searched for recent advances in diagnosis.
RESULTS AND CONCLUSIONS: Myelomatous pleurisy is a rare complication of MM. Its clinical and laboratory findings are non-specific. Definitive diagnosis relies on the histopathology of pleural biopsy or pleural effusion. Thoracoscopic pleural biopsy is reliable, safe and effective. Chemotherapy is the mainstay of treatment for myelomatous pleural effusion. However, the response rate is low with an overall median survival time of 4 months.
Li-Li Zhang; Yuan-Yuan Li; Cheng-Ping Hu; Hua-Ping Yang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of thoracic disease     Volume:  6     ISSN:  2072-1439     ISO Abbreviation:  J Thorac Dis     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-08-05     Completed Date:  2014-08-05     Revised Date:  2014-08-07    
Medline Journal Info:
Nlm Unique ID:  101533916     Medline TA:  J Thorac Dis     Country:  China    
Other Details:
Languages:  eng     Pagination:  E152-9     Citation Subset:  -    
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