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Myeloid marker S100A8/A9 and lymphocytemarker soluble interleukin 2 receptor: Biomarkers of hidradenitis suppurativa disease activity?
MedLine Citation:
PMID:  23320892     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Hidradenitis suppurative (HS) is a chronic inflammatory and debilitating disease of the skin. No biomarkers for this disease exist. OBJECTIVES: We set out to test if Angiotensin Converting Enzyme (ACE), lysozyme, soluble interleukin (IL-)2 Receptor (sIL-2R) and S100A8/A9 (calprotectin) are elevated in patients suffering from HS. METHODS: Serum was collected from 29 HS patients suffering from different stages of the disease and from 51 controls. ACE, lysozyme, sIL-2R and S100A8/A9 were measured. Clinical observation of disease activity was scored according to the Hurley grading system and by a physician global disease score (PGS) of disease severity. RESULTS: Serum levels of lysozyme and ACE were not increased above the normal reference values in controls or HS patients. sIL-2 and S100A8/A9 levels were significantly higher in HS patients than in controls (P < 0.001 for sIL-2 and S100A8/A9). Based on the receiver operating characteristic (ROC) curves, the optimum sIL-2R and S100A8/A9 cut-off values were 375 U/mL and 680 ng/mL respectively with a sensitivity of 0.79 and specificity of 0.78 for sIL-2R and 0.86 and 0.88 for S100A8/A9. No correlations with Hurley classification scores were found. However, when using PGS of disease activity to categorize patients, S100A/A9 but not sIL-2R levels tended to be higher in patients suffering from more active disease. CONCLUSIONS: S100A8/A9 and sIL-2R but not ACE or lysozyme are elevated in serum of patients suffering from HS. However, there is no correlation between S100A8/A9 or sIL-2R levels and disease stage according to the Hurley classification system. Further research is needed to study the potential of S100A8/A9 to score disease activity in larger cohorts of patients and to predict disease flares.
Authors:
C W Wieland; T Vogl; A Ordelman; H G M Vloedgraven; L H A Verwoolde; J M Rensen; J Roth; J Boer; J Hessels
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©The Authors BJD © 2013 British Association of Dermatologists.
Affiliation:
Laboratory for Clinical Chemistry, DeventerHospital, Deventer, The Netherlands.
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