| Myeloid marker S100A8/A9 and lymphocytemarker soluble interleukin 2 receptor: Biomarkers of hidradenitis suppurativa disease activity? | |
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MedLine Citation:
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PMID: 23320892 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Hidradenitis suppurative (HS) is a chronic inflammatory and debilitating disease of the skin. No biomarkers for this disease exist. OBJECTIVES: We set out to test if Angiotensin Converting Enzyme (ACE), lysozyme, soluble interleukin (IL-)2 Receptor (sIL-2R) and S100A8/A9 (calprotectin) are elevated in patients suffering from HS. METHODS: Serum was collected from 29 HS patients suffering from different stages of the disease and from 51 controls. ACE, lysozyme, sIL-2R and S100A8/A9 were measured. Clinical observation of disease activity was scored according to the Hurley grading system and by a physician global disease score (PGS) of disease severity. RESULTS: Serum levels of lysozyme and ACE were not increased above the normal reference values in controls or HS patients. sIL-2 and S100A8/A9 levels were significantly higher in HS patients than in controls (P < 0.001 for sIL-2 and S100A8/A9). Based on the receiver operating characteristic (ROC) curves, the optimum sIL-2R and S100A8/A9 cut-off values were 375 U/mL and 680 ng/mL respectively with a sensitivity of 0.79 and specificity of 0.78 for sIL-2R and 0.86 and 0.88 for S100A8/A9. No correlations with Hurley classification scores were found. However, when using PGS of disease activity to categorize patients, S100A/A9 but not sIL-2R levels tended to be higher in patients suffering from more active disease. CONCLUSIONS: S100A8/A9 and sIL-2R but not ACE or lysozyme are elevated in serum of patients suffering from HS. However, there is no correlation between S100A8/A9 or sIL-2R levels and disease stage according to the Hurley classification system. Further research is needed to study the potential of S100A8/A9 to score disease activity in larger cohorts of patients and to predict disease flares. |
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Authors:
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C W Wieland; T Vogl; A Ordelman; H G M Vloedgraven; L H A Verwoolde; J M Rensen; J Roth; J Boer; J Hessels |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-16 |
Journal Detail:
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Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: Br. J. Dermatol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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©The Authors BJD © 2013 British Association of Dermatologists. |
Affiliation:
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Laboratory for Clinical Chemistry, DeventerHospital, Deventer, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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