| Myeloid leukemia in down syndrome. | |
| | |
MedLine Citation:
|
PMID: 22150305 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Although adults with Down syndrome (DS) show a decreased incidence of cancer compared to individuals without DS, children with DS are at an increased risk of leukemia. Nearly half of these childhood leukemias are classified as acute megakaryoblastic leukemia (AMKL), a relatively rare subtype of acute myeloid leukemia (AML). Here, we summarize the clinical features of myeloid leukemia in DS, review recent research on the mechanisms of leukemogenesis, including the roles of GATA1 mutations and trisomy 21, and discuss treatment strategies. Given that trisomy 21 is a relatively common event in hematologic malignancies, greater knowledge of how the genes on chromosome 21 contribute to DS-AMKL will increase our understanding of a broader class of patients with leukemia. |
| | |
Authors:
|
Irum Khan; Sebastien Malinge; John Crispino |
Related Documents
:
|
7668225 - Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome secondary to pancreatitis. 3227005 - Jeune syndrome associated with pancreatic fibrosis. 893705 - Role-played and hypnotically induced simulation of psychopathology on the mmpi. 21993675 - Treatment with lenalidomide does not appear to increase the risk of leukemia progressio... 6945155 - Nasopharyngeal dysmorphology in the syndromes of apert and crouzon. 7812195 - The 5q- syndrome: a scientific and clinical update. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Critical reviews in oncogenesis Volume: 16 ISSN: 0893-9675 ISO Abbreviation: Crit Rev Oncog Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8914610 Medline TA: Crit Rev Oncog Country: United States |
Other Details:
|
Languages: eng Pagination: 25-36 Citation Subset: IM |
Affiliation:
|
Division of Hematology/Oncology, Northwestern University, Chicago Illinois. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Understanding the Biology of CRLF2-Overexpressing Acute Lymphoblastic Leukemia.
Next Document: CREB and Leukemogenesis.