| Myeloid dendritic cell lectins and their role in immune responses. | |
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MedLine Citation:
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PMID: 17979024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dendritic cells are bone marrow-derived professional antigen-presenting cells which link innate and adaptive immune responses. Acting as sentinels of the immune system, dendritic cells are loaded with a large array of antigen-capturing and pathogen-recognition receptors which constantly sample the surrounding extracellular environment for 'danger signals'. However, dendritic cells also exhibit a naive T-lymphocyte-activating ability and, depending on their maturation status, promote either immunological tolerance or primary immune responses. This functional ambivalence has brought dendritic cells to the focus of attention for immunotherapy protocols in autoimmune diseases, cancer and transplantation. |
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Authors:
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Angeles Dominguez-Soto; Angel L Corbi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in investigational drugs (London, England : 2000) Volume: 8 ISSN: 1472-4472 ISO Abbreviation: Curr Opin Investig Drugs Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2008-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100965718 Medline TA: Curr Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 910-20 Citation Subset: IM |
Affiliation:
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Centro de Investigaciones Biológicas (CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Motifs Amino Acid Sequence Animals Dendritic Cells / immunology* Humans Immunity / immunology* Lectins, C-Type / genetics, immunology*, physiology Models, Immunological Multigene Family Signal Transduction / immunology |
| Chemical | |
Reg. No./Substance:
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0/Lectins, C-Type |
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