| Myelodysplastic syndrome with trisomy 8 associated with Behçet syndrome: an immunologic link to a karyotypic abnormality. | |
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MedLine Citation:
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PMID: 17066465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myelodysplastic syndrome (MDS) in children is often associated with chromosomal anomalies and trisomy 8 is a characteristic karyotypic feature in up to 20% of the cases. Behçet disease is a rare multisystem inflammatory disorder characterized by recurrent mouth and genital ulcers. MDS with trisomy 8 has been observed in adult patients with Behçet syndrome with some cases developing prior to the clinical manifestations of the latter. We present a female with a similar association and explain the importance of identifying the coexisting conditions. The immunological abnormalities, which may be observed in MDS and their possible mechanisms, are also discussed. |
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Authors:
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Jecko V Thachil; Rahuman Salim; Anne Field; Robert Moots; Paula Bolton-Maggs |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 50 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-01-15 Completed Date: 2008-02-12 Revised Date: 2009-01-12 |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 649-51 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. |
Affiliation:
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Department of Haematology, Royal Liverpool University Hospital, Liverpool, United Kingdom. jeckothachil@yahoo.co.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anemia, Refractory / etiology*, genetics, immunology Behcet Syndrome / diagnosis, drug therapy, genetics*, immunology Chromosomes, Human, Pair 8* Female Humans Immunologic Deficiency Syndromes / etiology Immunosuppressive Agents / therapeutic use Karyotyping Oral Ulcer / drug therapy, etiology Tacrolimus / therapeutic use Thalidomide / therapeutic use Trisomy* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 50-35-1/Thalidomide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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