Document Detail

Myelodysplastic syndrome with isolated deletion of chromosome 20q: an indolent disease with minimal morphological dysplasia and frequent thrombocytopenic presentation.
MedLine Citation:
PMID:  17764468     Owner:  NLM     Status:  MEDLINE    
The present study analysed the clinicopathological features of nine myelodysplastic syndrome (MDS) patients in which del(20q) was the sole cytogenetic abnormality and a control group of 17 adult patients with idiopathic thrombocytopenic purpura (ITP). Seven of nine del(20q) patients were thrombocytopenic and six of nine were mildly anaemic at presentation. There was no significant morphological dysplasia identified in the del(20q) group as compared with the ITP group. These results indicate that MDS with del(20q) commonly presents with thrombocytopenia and has minimal morphological dysplasia. Cytogenetic analysis on adult patients undergoing bone marrow sampling for thrombocytopenia may help avoid misdiagnosis of MDS with del(20q) as ITP.
Raavi Gupta; Chad P Soupir; Vandita Johari; Robert P Hasserjian
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Publication Detail:
Type:  Journal Article     Date:  2007-08-30
Journal Detail:
Title:  British journal of haematology     Volume:  139     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-27     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  265-8     Citation Subset:  IM    
Department of Pathology, Columbia University Medical Center, New York, NY, USA.
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MeSH Terms
Aged, 80 and over
Base Sequence
Case-Control Studies
Diagnosis, Differential
Middle Aged
Myelodysplastic Syndromes / blood,  genetics*
Purpura, Thrombocytopenic, Idiopathic / genetics
Sequence Deletion*
Statistics, Nonparametric
Thrombocytopenia / genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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