| Myelodysplastic syndrome presenting as generalized granulomatous dermatitis. | |
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MedLine Citation:
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PMID: 21422341 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Granulomatous dermatitis has rarely been reported as a manifestation of leukemia or myelodysplastic syndrome (MDS). We describe a case of widespread granulomatous dermatitis that preceded the diagnosis of MDS by 2 years. OBSERVATIONS: A 71-year-old man developed a generalized, mildly pruritic eruption that slowly progressed over a 2-year period. Punch biopsy specimens demonstrated interstitial dermal granulomatous inflammation. A complete blood cell count with differential showed marked monocytosis, and the findings of a subsequent biopsy of the bone marrow confirmed MDS. Lenalidomide therapy was initiated, and the patient's skin condition improved after 6 weeks of treatment; however, his MDS progressed to acute myeloid leukemia, and he died shortly thereafter. CONCLUSIONS: There is a paucity of literature documenting the occurrence of granulomatous dermatitis as a manifestation of an underlying hematologic disorder. This case illustrates a striking example of widespread granulomatous dermatitis heralding the onset of MDS. It is imperative that the dermatologic community recognize the rare association of granulomatous dermatitis with myelodysplasia, because the cutaneous manifestations may be the presenting finding and can precede the development of leukemia by several years. |
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Authors:
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Samuel J Balin; David A Wetter; Paul J Kurtin; Louis Letendre; Mark R Pittelkow |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of dermatology Volume: 147 ISSN: 1538-3652 ISO Abbreviation: Arch Dermatol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 331-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905. wetter.david@mayo.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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