| Myelodysplasia and autoimmunity. | |
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MedLine Citation:
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PMID: 22157417 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Primary myelodysplastic syndromes (MDS) are heterogeneous clonal haemopoietic stem-cell disorders clinically presented with a varying degree of peripheral cytopenias and an increased probability of leukemic evolution. The natural history of MDS ranges from more indolent forms of disease spanning years to those rapidly progressing to overt leukemia. A distinct subset of MDS patients manifest overt autoimmune manifestations (AIMs), the pathogenesis and prognostic significance of which remain controversial. This review will briefly highlight aspects of immune-mediated myelosuppression and cytokine-induced cytopenias in MDS and further analyze MDS-associated AIMs clinically and pathogenetically. RECENT FINDINGS: Facts provided by advanced studies suggest that an immune reaction against the evolving clone, operated by macrophages, T, natural killer and other effectors contribute to ineffective and dysplastic MDS hemopoiesis. Despite the fact that several immunologic abnormalities have been described in MDS, the precise pathophysiologic mechanism underlying AIMs remains unclear. SUMMARY: The encouraging biological insights into the autoimmune component of MDS pathophysiology can lead to the development of novel forms of treatment for controlling MDS process. MDS with AIMs constitute an ideal model in the investigation of disordered immune function in preleukemic states. |
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Authors:
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Stavroula Giannouli; Theoni Kanellopoulou; Michael Voulgarelis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in rheumatology Volume: 24 ISSN: 1531-6963 ISO Abbreviation: Curr Opin Rheumatol Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9000851 Medline TA: Curr Opin Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 97-102 Citation Subset: IM |
Affiliation:
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a2nd Department of Internal Medicine bDepartment of Pathophysiology, Medical School, National University of Athens, Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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