Document Detail


Myeloablative therapy and bone marrow transplantation in Jehovah's Witnesses with malignancies: single center experience.
MedLine Citation:
PMID:  12900781     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hematological malignancies in Jehovah's Witnesses are often difficult to cure since these patients deny transfusions. By a retrospective analysis, we report the possibility of treating some tumors, mostly hematological, with either autologous or allogeneic bone marrow transplantation (BMT) without blood support. Eight patients were evaluated, including lymphoma (two patients), acute lymphoblastic (one patient) and myeloblastic (one patient) leukemia, chronic lymphocytic leukemia (one patient), refractory anemia with blasts in transformation (one patient), chronic myeloid leukemia (one patient) and metastatic breast cancer (one patient). All patients experienced a severe cytopenia with no major side effects or life-threatening complications. We had four deaths: three from relapse and progression of the disease (at 5, 8 and 15 months after the stem cell infusion), and one from acute intestinal GVHD (at 2 months after the stem cell infusion). Four patients are in complete clinical remission (at 8, 10, 16 and 26 months after the stem cell infusion), and this was related to the disease outcome. We conclude that autologous and allogeneic BMT are feasible without the support of transfusions. We believe that this should be performed as soon as possible in the course of the disease.
Authors:
P Mazza; A Prudenzano; B Amurri; G Palazzo; G Pisapia; L Stani; G Pricolo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  32     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-05     Completed Date:  2004-05-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  433-6     Citation Subset:  IM    
Affiliation:
Struttura Complessa di Ematologia, Azienda Ospedaliera SS.Annunziata, Taranto, Italy. ematologia.taranto@tin.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia / therapy
Blood Transfusion*
Bone Marrow Transplantation / methods*
Disease Progression
Female
Humans
Jehovah's Witnesses*
Leukemia / therapy*
Leukemia, Lymphocytic, Chronic, B-Cell / therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
Leukemia, Myeloid, Acute / therapy
Lymphoma / therapy*
Male
Middle Aged
Myeloablative Agonists / therapeutic use*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
Recurrence
Religion and Medicine
Retrospective Studies
Time Factors
Transplantation Conditioning
Treatment Outcome
Treatment Refusal
Chemical
Reg. No./Substance:
0/Myeloablative Agonists

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