| Myeloablative therapy and bone marrow transplantation in Jehovah's Witnesses with malignancies: single center experience. | |
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MedLine Citation:
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PMID: 12900781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hematological malignancies in Jehovah's Witnesses are often difficult to cure since these patients deny transfusions. By a retrospective analysis, we report the possibility of treating some tumors, mostly hematological, with either autologous or allogeneic bone marrow transplantation (BMT) without blood support. Eight patients were evaluated, including lymphoma (two patients), acute lymphoblastic (one patient) and myeloblastic (one patient) leukemia, chronic lymphocytic leukemia (one patient), refractory anemia with blasts in transformation (one patient), chronic myeloid leukemia (one patient) and metastatic breast cancer (one patient). All patients experienced a severe cytopenia with no major side effects or life-threatening complications. We had four deaths: three from relapse and progression of the disease (at 5, 8 and 15 months after the stem cell infusion), and one from acute intestinal GVHD (at 2 months after the stem cell infusion). Four patients are in complete clinical remission (at 8, 10, 16 and 26 months after the stem cell infusion), and this was related to the disease outcome. We conclude that autologous and allogeneic BMT are feasible without the support of transfusions. We believe that this should be performed as soon as possible in the course of the disease. |
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Authors:
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P Mazza; A Prudenzano; B Amurri; G Palazzo; G Pisapia; L Stani; G Pricolo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bone marrow transplantation Volume: 32 ISSN: 0268-3369 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-05 Completed Date: 2004-05-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: England |
Other Details:
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Languages: eng Pagination: 433-6 Citation Subset: IM |
Affiliation:
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Struttura Complessa di Ematologia, Azienda Ospedaliera SS.Annunziata, Taranto, Italy. ematologia.taranto@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anemia / therapy Blood Transfusion* Bone Marrow Transplantation / methods* Disease Progression Female Humans Jehovah's Witnesses* Leukemia / therapy* Leukemia, Lymphocytic, Chronic, B-Cell / therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy Leukemia, Myeloid, Acute / therapy Lymphoma / therapy* Male Middle Aged Myeloablative Agonists / therapeutic use* Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy Recurrence Religion and Medicine Retrospective Studies Time Factors Transplantation Conditioning Treatment Outcome Treatment Refusal |
| Chemical | |
Reg. No./Substance:
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0/Myeloablative Agonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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