| Myelinopathia centralis diffusa (vanishing white matter disease): evidence of apoptotic oligodendrocyte degeneration in early lesion development. | |
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MedLine Citation:
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PMID: 11601505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe histopathological changes in a 2-year-old boy who died from myelinopathia centralis diffusa. Despite extensive white matter destruction, surprisingly high numbers of oligodendrocytes expressing proteolipid protein mRNA were detected. In an active demyelinating lesion in the brainstem, oligodendrocytes showed typical signs of apoptosis. We suggest that death of mature oligodendrocytes is the critical event in the disease. |
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Authors:
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W Brück; J Herms; K Brockmann; W Schulz-Schaeffer; F Hanefeld |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Annals of neurology Volume: 50 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-16 Completed Date: 2001-11-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 532-6 Citation Subset: IM |
Affiliation:
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Department of Neuropathology, University of Göttingen, Germany. wolfgang.brueck@charite.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis* Brain Diseases / pathology* Cerebral Cortex / pathology Child, Preschool Fatal Outcome Humans Male Myelin Sheath / pathology Oligodendroglia / pathology* |
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