| Myelination patterns on magnetic resonance of children with developmental delay. | |
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MedLine Citation:
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PMID: 1691996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance (MR) imaging was performed in 30 children with unexplained developmental delay who had associated neurological abnormalities such as seizures, spasticity, hypotonia, ataxia or poor vision. No child had a history of regression, preterm birth or neonatal cerebral injury. CT scans were performed before MR in all cases and were either normal or showed only mild atrophy. At least two MR sequences were obtained for all patients. Nine children had delayed or absent myelination on MR, one had patchy white-matter abnormalities, and in one patient myelination was topographically normal, but of inappropriately low signal intensity. MR was abnormal in six of seven children who had abnormal brainstem auditory evoked potentials (BAEP), and was normal in nine of 11 patients who had a normal BAEP. MR may have a useful rôle in demonstrating abnormal white-matter maturation in children with unexplained neurodevelopmental delay, particularly when abnormalities are found on BAEP studies. |
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Authors:
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M G Harbord; J P Finn; M A Hall-Craggs; S A Robb; B E Kendall; S G Boyd |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental medicine and child neurology Volume: 32 ISSN: 0012-1622 ISO Abbreviation: Dev Med Child Neurol Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-06-04 Completed Date: 1990-06-04 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 295-303 Citation Subset: IM |
Affiliation:
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Hospitals for Sick Children, London. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology* Child Child, Preschool Developmental Disabilities / diagnosis* Female Humans Infant Magnetic Resonance Imaging* Male Nerve Fibers, Myelinated / pathology* Tomography, X-Ray Computed |
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