Document Detail

Myelination patterns on magnetic resonance of children with developmental delay.
MedLine Citation:
PMID:  1691996     Owner:  NLM     Status:  MEDLINE    
Magnetic resonance (MR) imaging was performed in 30 children with unexplained developmental delay who had associated neurological abnormalities such as seizures, spasticity, hypotonia, ataxia or poor vision. No child had a history of regression, preterm birth or neonatal cerebral injury. CT scans were performed before MR in all cases and were either normal or showed only mild atrophy. At least two MR sequences were obtained for all patients. Nine children had delayed or absent myelination on MR, one had patchy white-matter abnormalities, and in one patient myelination was topographically normal, but of inappropriately low signal intensity. MR was abnormal in six of seven children who had abnormal brainstem auditory evoked potentials (BAEP), and was normal in nine of 11 patients who had a normal BAEP. MR may have a useful rôle in demonstrating abnormal white-matter maturation in children with unexplained neurodevelopmental delay, particularly when abnormalities are found on BAEP studies.
M G Harbord; J P Finn; M A Hall-Craggs; S A Robb; B E Kendall; S G Boyd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  32     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-06-04     Completed Date:  1990-06-04     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  295-303     Citation Subset:  IM    
Hospitals for Sick Children, London.
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MeSH Terms
Brain / pathology*
Child, Preschool
Developmental Disabilities / diagnosis*
Magnetic Resonance Imaging*
Nerve Fibers, Myelinated / pathology*
Tomography, X-Ray Computed

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