Document Detail

Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system.
MedLine Citation:
PMID:  9373037     Owner:  NLM     Status:  MEDLINE    
The establishment and operation of the nervous system requires genetic regulation by a network of DNA-binding proteins, among which is the zinc finger superfamily of transcription factors. We have cloned and characterized a member of the unusual Cys-Cys-His-Cys (also referred to as Cys2HisCys, CCHC, or C2HC) class of zinc finger proteins in the developing nervous system. The novel gene, Myt1-like (Myt1l), is highly homologous to the original representative of this class, Myelin transcription factor 1 (Myt1) (Kim and Hudson, 1992). The MYT1 gene maps to human chromosome 20, while MYT1L maps to a region of human chromosome 2. Both zinc finger proteins are found in neurons at early stages of differentiation, with germinal zone cells displaying intense staining for MyT1. Unlike Myt1, Myt1l has not been detected in the glial lineage. Neurons that express Myt1l also express TuJ1, which marks neurons around the period of terminal mitosis. The Myt1l protein resides in distinct domains within the neuronal nucleus, analogous to the discrete pattern previously noted for Myt1 (Armstrong et al.: 14:303-321, 1995). The developmental expression and localization of these two multifingered CCHC proteins suggests that each may play a role in the development of neurons and oligodendroglia in the mammalian central nervous system.
J G Kim; R C Armstrong; D v Agoston; A Robinsky; C Wiese; J Nagle; L D Hudson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  50     ISSN:  0360-4012     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-01-12     Completed Date:  1998-01-12     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  272-90     Citation Subset:  IM    
Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4160, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF004294;  AF004295
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MeSH Terms
Amino Acid Sequence
Base Sequence
Cell Aging
Cell Line
Central Nervous System / cytology,  embryology*
Chromosome Mapping
DNA, Complementary / genetics
DNA-Binding Proteins*
Embryonic and Fetal Development / physiology
Mice / embryology
Molecular Sequence Data
Neurons / metabolism*
Oligodendroglia / metabolism*
Protein-Serine-Threonine Kinases / genetics,  metabolism*
Protein-Tyrosine Kinases / genetics,  metabolism*
RNA, Messenger / metabolism
Transcription Factors*
Zinc Fingers / physiology*
Reg. No./Substance:
0/DNA, Complementary; 0/DNA-Binding Proteins; 0/MYT1 protein, human; 0/RNA, Messenger; 0/Transcription Factors; EC Kinases; EC protein, human; EC Kinases

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