| Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. | |
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MedLine Citation:
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PMID: 9373037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The establishment and operation of the nervous system requires genetic regulation by a network of DNA-binding proteins, among which is the zinc finger superfamily of transcription factors. We have cloned and characterized a member of the unusual Cys-Cys-His-Cys (also referred to as Cys2HisCys, CCHC, or C2HC) class of zinc finger proteins in the developing nervous system. The novel gene, Myt1-like (Myt1l), is highly homologous to the original representative of this class, Myelin transcription factor 1 (Myt1) (Kim and Hudson, 1992). The MYT1 gene maps to human chromosome 20, while MYT1L maps to a region of human chromosome 2. Both zinc finger proteins are found in neurons at early stages of differentiation, with germinal zone cells displaying intense staining for MyT1. Unlike Myt1, Myt1l has not been detected in the glial lineage. Neurons that express Myt1l also express TuJ1, which marks neurons around the period of terminal mitosis. The Myt1l protein resides in distinct domains within the neuronal nucleus, analogous to the discrete pattern previously noted for Myt1 (Armstrong et al.: 14:303-321, 1995). The developmental expression and localization of these two multifingered CCHC proteins suggests that each may play a role in the development of neurons and oligodendroglia in the mammalian central nervous system. |
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Authors:
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J G Kim; R C Armstrong; D v Agoston; A Robinsky; C Wiese; J Nagle; L D Hudson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neuroscience research Volume: 50 ISSN: 0360-4012 ISO Abbreviation: J. Neurosci. Res. Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1998-01-12 Completed Date: 1998-01-12 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 272-90 Citation Subset: IM |
Affiliation:
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Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4160, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AF004294; AF004295 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Cell Aging Cell Line Central Nervous System / cytology, embryology* Chromosome Mapping DNA, Complementary / genetics DNA-Binding Proteins* Embryonic and Fetal Development / physiology Humans Mice / embryology Molecular Sequence Data Neurons / metabolism* Oligodendroglia / metabolism* Protein-Serine-Threonine Kinases / genetics, metabolism* Protein-Tyrosine Kinases / genetics, metabolism* RNA, Messenger / metabolism Transcription Factors* Zinc Fingers / physiology* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Complementary; 0/DNA-Binding Proteins; 0/MYT1 protein, human; 0/RNA, Messenger; 0/Transcription Factors; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.11.1/PKMYT1 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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