Document Detail


Myelin repair strategies: a cellular view.
MedLine Citation:
PMID:  18451710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The development of successful myelin repair strategies depends on the detailed knowledge of the cellular and molecular processes underlying demyelination and remyelination in the central nervous system of animal models and in patients with multiple sclerosis (MS). Based on the complexity of the demyelination and remyelination processes, it should be expected that effective therapeutic approaches will require a combination of strategies for immunomodulation, neuroprotection, and myelin replacement. This brief review highlights recent cellular and molecular findings and indicates that future therapeutic strategies to enhance remyelination may also require combinatorial treatment to accomplish.
RECENT FINDINGS: The relapsing-remitting course of some forms of multiple sclerosis has typically fueled hope for effective repair of multiple sclerosis lesions, if demyelinating activity could be attenuated. Recent findings support the potential of endogenous neural stem cells and progenitor cells to generate remyelinating oligodendrocytes. Importantly, interactions with viable axons and supportive astrocytic responses are required for endogenous immature cells to fulfill their potential remyelinating capacity.
SUMMARY: The research described here will help in identifying the major obstacles to effective remyelination and potential therapeutic targets to guide development of comprehensive approaches for testing in animal models and eventual treatment of patients with multiple sclerosis.
Authors:
Vittorio Gallo; Regina C Armstrong
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  21     ISSN:  1350-7540     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-07-25     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  278-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult Stem Cells / cytology*
Animals
Astrocytes / pathology
Axons / pathology*
Humans
Multiple Sclerosis / metabolism,  pathology*,  therapy
Myelin Sheath / metabolism,  pathology*
Oligodendroglia / cytology*
Grant Support
ID/Acronym/Agency:
P30 HD040677/HD/NICHD NIH HHS; P30 HD040677-08/HD/NICHD NIH HHS; P30HD40677/HD/NICHD NIH HHS; R01 NS039293/NS/NINDS NIH HHS; R01 NS039293-08/NS/NINDS NIH HHS; R01 NS045702/NS/NINDS NIH HHS; R01 NS045702-05/NS/NINDS NIH HHS; R01 NS056427/NS/NINDS NIH HHS; R01 NS056427-03/NS/NINDS NIH HHS; R01NS045702/NS/NINDS NIH HHS; R01NS1056427/NS/NINDS NIH HHS; R01NS39293/NS/NINDS NIH HHS; RG4019/RG/CSR NIH HHS
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