| Myelin phagocytosis and remyelination of macrophage-enriched central nervous system aggregate cultures. | |
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MedLine Citation:
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PMID: 11746450 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An increased level of myelin basic protein (MBP) degradation peptide 80-89, representative of myelin breakdown, is detected in myelinating foetal rat brain aggregate cultures supplemented with peritoneal macrophages at a time coinciding with the onset of myelination. During the period of myelination, the proportion of activated macrophages/microglia in the aggregates decreases, accompanied by a reduction in the content of MBP degradation products. During the recovery period following a demyelinating episode, the rate of MBP synthesis in antibody-treated standard aggregates was greater than in their medium controls. However, the rate of MBP accumulation was not as efficient in macrophage-enriched aggregates and was associated with persistently raised MBP peptide levels. Thus, as occurs in multiple sclerosis lesions, attempts at remyelination appear to be counterbalanced by macrophage-mediated demyelination, with the continued presence of degraded myelin rendering a local environment that is not fully conducive to remyelination. |
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Authors:
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C A Copelman; L T Diemel; D Gveric; N A Gregson; M L Cuzner |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroscience research Volume: 66 ISSN: 0360-4012 ISO Abbreviation: J. Neurosci. Res. Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-17 Completed Date: 2002-01-24 Revised Date: 2011-08-23 |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: United States |
Other Details:
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Languages: eng Pagination: 1173-8 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Wiley-Liss, Inc. |
Affiliation:
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Department of Neurochemistry, Institute of Neurology, University College London, 1 Wakefield Street, London, WC1N 1PJ, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Antibodies / pharmacology Antigens, CD* Antigens, CD147 Antigens, Neoplasm* Antigens, Surface* Avian Proteins* Blood Proteins* Brain / embryology*, immunology, metabolism Cell Count Cell Size / immunology Cells, Cultured / drug effects, immunology, metabolism Ectodysplasins Fetus Humans Immunohistochemistry Macrophages / drug effects, immunology, metabolism* Membrane Glycoproteins / metabolism Membrane Proteins / metabolism Middle Aged Multiple Sclerosis / immunology, metabolism*, physiopathology Myelin Basic Proteins / immunology, metabolism* Myelin Sheath / immunology, metabolism*, pathology Myelin-Associated Glycoprotein / antagonists & inhibitors, immunology, metabolism Nerve Regeneration / immunology* Peptide Fragments / immunology, metabolism Phagocytosis / immunology* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antigens, CD; 0/Antigens, Neoplasm; 0/Antigens, Surface; 0/Avian Proteins; 0/BSG protein, human; 0/Blood Proteins; 0/Bsg protein, Gallus gallus; 0/Bsg protein, rat; 0/EDA protein, human; 0/Ectodysplasins; 0/Membrane Glycoproteins; 0/Membrane Proteins; 0/Myelin Basic Proteins; 0/Myelin-Associated Glycoprotein; 0/Peptide Fragments; 0/myelin oligodendrocyte glycoprotein; 136894-56-9/Antigens, CD147 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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