| Myelin basic protein and the stability of the multilamellar myelin structure. | |
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MedLine Citation:
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PMID: 6191815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A purified myelin fraction was prepared from myelin deficient (mld) mutant mice and normal littermates (20 to 25 days old). Mld brains contained only 5% of the amount of myelin present in controls. Myelin isolated from mld brains had a normal lipid and protein content. The lipid composition of mld myelin was also normal. Myelin basic protein (MBP) was nearly missing in mld myelin. At the electron microscope, in mld myelin, the major dense line was often missing and the myelin lamellae were uncompacted. The high specific radioactivity of the myelin associated glycoprotein and sulfatides, two myelin constituents which are not affected by the mutation, indicate a high turnover rate of myelin membranes in the mld mutant. Furthermore, the presence of increased amounts of cholesterol esters in mld brains suggests that myelin in mld mutants is unstable. We propose that MBP, which is responsible in the central nervous system for myelin compaction, is responsible for the stability of this membrane. |
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Authors:
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J M Matthieu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften Volume: - ISSN: 0036-7494 ISO Abbreviation: Bull Schweiz Akad Med Wiss Publication Date: 1981-1982 |
Date Detail:
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Created Date: 1983-09-23 Completed Date: 1983-09-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503414 Medline TA: Bull Schweiz Akad Med Wiss Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 101-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism Lipids / isolation & purification Mice Mice, Mutant Strains Myelin Basic Proteins / isolation & purification* Myelin Proteins / analysis Myelin Sheath / analysis*, ultrastructure Myelin-Associated Glycoprotein Sulfoglycosphingolipids / analysis |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Myelin Basic Proteins; 0/Myelin Proteins; 0/Myelin-Associated Glycoprotein; 0/Sulfoglycosphingolipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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