| Myelin basic protein and S-100 antigen in cerebrospinal fluid of patients with multiple sclerosis in the acute phase. | |
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MedLine Citation:
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PMID: 2581917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has previously been demonstrated that both Myelin Basic Protein (MBP) and S-100 are released in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients during acute phases of exacerbation of the disease. In order to investigate the pathobiological significance of the release of these two proteins into the CSF, MBP and S-100 were assayed in 10 MS patients during the five weeks following onset of an acute exacerbation. MBP was detectable in CSF during the first three weeks after exacerbation, while S-100 was detectable during the entire period of observation, at least in some of the patients. MBP reached its highest CSF concentrations during the first two weeks while S-100 did so in the third week, decreasing thereafter. This difference in time of presence of MBP and S-100 in the CSF is probably due to the different biological origin, MBP being a marker of myelin sheath injury, and S-100, more probably, of astrocytic activity. |
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Authors:
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A R Massaro; F Michetti; A Laudisio; P Bergonzi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Italian journal of neurological sciences Volume: 6 ISSN: 0392-0461 ISO Abbreviation: Ital J Neurol Sci Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-06-26 Completed Date: 1985-06-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8006502 Medline TA: Ital J Neurol Sci Country: ITALY |
Other Details:
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Languages: eng Pagination: 53-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Humans Male Middle Aged Multiple Sclerosis / cerebrospinal fluid* Myelin Basic Proteins / cerebrospinal fluid* S100 Proteins / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
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0/Myelin Basic Proteins; 0/S100 Proteins |
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