Document Detail

Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin.
MedLine Citation:
PMID:  10103078     Owner:  NLM     Status:  MEDLINE    
We previously reported that myelin-associated oligodendrocytic basic protein (MOBP) was abundantly expressed in the central nervous system (CNS) myelin, and shared several characteristics with myelin basic protein (MBP). In particular, a cluster of positively charged amino acids was considered to facilitate compaction of the cytoplasmic face of the myelin sheath, as in the case of MBP. However, the contribution of MOBP in forming and maintaining the myelin sheath still remains unclear. Recent investigations showed that one isoform of MOBP was expressed in the embryo prior to myelination, and MOBP isoforms were colocalized with the microtubular network and nucleus in vitro. To explore the role of MOBP in vivo, we generated MOBP-deficient mice and analysed the CNS myelin. Surprisingly, the compact myelin was formed, however, the myelin from MOBP-deficient mice exposed to hexachlorophene, a known dysmyelinating agent, showed widening of the major dense lines. These results suggest that MOBP is not essential for myelin formation, but reinforces the apposition of the cytoplasmic faces of the myelin sheath. A striking phenotype of MOBP-deficient mice was the presence of the straight 'condensed' radial component. This component has been described as a tight junction-like complex running radially and zig-zag through the CNS myelin sheath between inner and outer mesaxons. These results suggest that MOBP is essential for normal arrangement of the radial component.
Y Yamamoto; H Yoshikawa; S Nagano; G Kondoh; S Sadahiro; T Gotow; T Yanagihara; S Sakoda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  11     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-26     Completed Date:  1999-04-26     Revised Date:  2011-08-23    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  847-55     Citation Subset:  IM    
Department of Neurology, Osaka University Medical School, 2-2 Yamada- oka, Suita, Osaka 5650-0871, Japan.
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MeSH Terms
Anti-Infective Agents, Local
Blotting, Southern
Cytoplasm / chemistry,  physiology,  ultrastructure
Freeze Fracturing
Lipids / analysis
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Mutant Strains
Microscopy, Electron
Motor Activity / physiology
Myelin Sheath / chemistry*,  physiology,  ultrastructure
Myelin-Associated Glycoprotein / genetics*,  metabolism
Oligodendroglia / chemistry*,  physiology*,  ultrastructure
Optic Nerve / chemistry,  cytology,  physiology
Spinal Cord / chemistry,  cytology,  physiology
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Lipids; 0/Myelin-Associated Glycoprotein; 0/myelin oligodendrocyte glycoprotein; 70-30-4/Hexachlorophene; 9002-93-1/Octoxynol

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