Document Detail


Myelin restoration: progress and prospects for human cell replacement therapies.
MedLine Citation:
PMID:  21461592     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oligodendrocytes are the primary source of myelin in the adult central nervous system (CNS), and their dysfunction or loss underlies several diseases of both children and adults. Dysmyelinating and demyelinating diseases are thus attractive targets for cell-based strategies since replacement of a single presumably homogeneous cell type has the potential to restore functional levels of myelin. To understand the obstacles that cell-replacement therapy might face, we review oligodendrocyte biology and emphasize aspects of oligodendrocyte development that will need to be recapitulated by exogenously transplanted cells, including migration from the site of transplantation, axon recognition, terminal differentiation, axon wrapping, and myelin production and maintenance. We summarize studies in which different types of myelin-forming cells have been transplanted into the CNS and highlight the continuing challenges regarding the use of cell-based therapies for human white matter disorders.
Authors:
Gregory B Potter; David H Rowitch; Magdalena A Petryniak
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-04-02
Journal Detail:
Title:  Archivum immunologiae et therapiae experimentalis     Volume:  59     ISSN:  1661-4917     ISO Abbreviation:  Arch. Immunol. Ther. Exp. (Warsz.)     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-04-14     Completed Date:  2011-07-29     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0114365     Medline TA:  Arch Immunol Ther Exp (Warsz)     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  179-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cell Movement
Cell- and Tissue-Based Therapy* / trends
Clinical Trials as Topic
Demyelinating Diseases / pathology,  physiopathology,  therapy*
Disease Models, Animal
Humans
Mice
Myelin Sheath / physiology*
Oligodendroglia / physiology*,  transplantation
Grant Support
ID/Acronym/Agency:
K08 NS062744/NS/NINDS NIH HHS; K08 NS062744/NS/NINDS NIH HHS; //Howard Hughes Medical Institute

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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