Document Detail

Mycotoxins in laboratory rodent feed.
MedLine Citation:
PMID:  15901367     Owner:  NLM     Status:  MEDLINE    
Twenty-one batches of fixed-formula rodent diets from three feed manufacturers were tested for the presence of five mycotoxins: deoxynivalenol (DON), nivalenol (NIV), HT-2 toxin, T-2 toxin and ochratoxin A (OTA). Five batches were also tested for the presence of zearalenone (ZEN) and six batches for aflatoxins. Detectable levels of DON (up to 298 microg/kg), NIV (up to 118 microg/kg), OTA (up to 3.1 microg/kg) or ZEN (up to 26.7 microg/kg) were found in samples from all manufacturers. Three batches contained two (DON or NIV and OTA or ZEN) and one batch contained three (DON, OTA and ZEN) different mycotoxins. Aflatoxins, T-2 and HT-2 were not detected in any of the batches. The concentrations of mycotoxins detected in the feed were low, but indicated that feed ingredients, probably the cereal ingredients, were contaminated by mycotoxins. Since mycotoxins are known to have toxic and/or immunosuppressive effects, non-contaminated ingredients should be used for production of laboratory animal feed. The results imply that an improved quality control of ingredients used for laboratory rodent feed should be implemented.
A Halldén Waldemarson; P Hedenqvist; A-C Salomonsson; P Häggblom
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Laboratory animals     Volume:  39     ISSN:  0023-6772     ISO Abbreviation:  Lab. Anim.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-19     Completed Date:  2005-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  England    
Other Details:
Languages:  eng     Pagination:  230-5     Citation Subset:  IM    
Veterinary Resources, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
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MeSH Terms
Animal Feed / analysis*,  toxicity
Animals, Laboratory*
Chromatography, High Pressure Liquid
Food Contamination / analysis*
Mycotoxins / analysis*
Reg. No./Substance:

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