Document Detail


Mycotoxins: food contamination, mechanism, carcinogenic potential and preventive measures.
MedLine Citation:
PMID:  2017214     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mycotoxins constitute a large number of naturally occurring fungal secondary metabolites with very diversified toxic effects in humans and animals. Among many mycotoxins discovered, aflatoxins, ochratoxin A, sterigmatocystin and several others are identified as carcinogens; several others were found to be mutagenic. Nevertheless, aflatoxin B1 has been found to be one of the most potent carcinogens and contamination of aflatoxins in the food supply is still a major concern. Whereas extensive studies have been made on aflatoxins, little is known about the mode of action of other carcinogenic and mutagenic mycotoxins. Recent progress on research for the carcinogenic and mutagenic mycotoxins is presented in this review with emphasis on their contamination in foods, their carcinogenic potential to humans, and the mode of action as well as possible preventive measures.
Authors:
F S Chu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Mutation research     Volume:  259     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1991-05-21     Completed Date:  1991-05-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  291-306     Citation Subset:  IM    
Affiliation:
Food Research Institute, University of Wisconsin-Madison 53706.
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MeSH Terms
Descriptor/Qualifier:
Aflatoxins / toxicity
Animals
Carcinogens
Food Contamination*
Humans
Mutagens
Mycotoxins / analysis,  toxicity*
Ochratoxins / toxicity
Sterigmatocystin / toxicity
Grant Support
ID/Acronym/Agency:
CA 15064/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Aflatoxins; 0/Carcinogens; 0/Mutagens; 0/Mycotoxins; 0/Ochratoxins; 10048-13-2/Sterigmatocystin; 303-47-9/ochratoxin A

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