Document Detail

Mycosporine-like amino acids (MAAs): chemical structure, biosynthesis and significance as UV-absorbing/screening compounds.
MedLine Citation:
PMID:  18697565     Owner:  NLM     Status:  MEDLINE    
Continuous depletion of the stratospheric ozone layer has resulted in an increase in ultraviolet-B (UV-B; 280-315 nm) radiation on the earth's surface which inhibits photochemical and photobiological processes. However, certain photosynthetic organisms have evolved mechanisms to counteract the toxicity of ultraviolet or high photosynthetically active radiation by synthesizing the UV-absorbing/screening compounds, such as mycosporine-like amino acids (MAAs) and scytonemin besides the repair of UV-induced damage of DNA and accumulation of carotenoids and detoxifying enzymes or radical quenchers and antioxidants. Chemical structure of various MAAs, their possible biochemical routes of synthesis and role as photoprotective compounds in various organisms are discussed.
Shailendra P Singh; Sunita Kumari; Rajesh P Rastogi; Kanchan L Singh; Rajeshwar P Sinha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  46     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-08-13     Completed Date:  2008-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  7-17     Citation Subset:  IM    
Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi 221 005, India.
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MeSH Terms
Algae / metabolism
Amino Acids / chemistry*
Antioxidants / metabolism
Cyanobacteria / metabolism
Cyclohexanols / chemistry*,  pharmacology
DNA / chemistry
Glycine / analogs & derivatives*,  chemistry,  pharmacology
Models, Biological
Models, Chemical
Molecular Structure
Oxygen / chemistry
Phytoplankton / metabolism*
Ultraviolet Rays
Reg. No./Substance:
0/Amino Acids; 0/Antioxidants; 0/Cyclohexanols; 0/mycosporine-2-glycine; 56-40-6/Glycine; 7782-44-7/Oxygen; 9007-49-2/DNA

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