Document Detail


Mycosporine glycine protects biological systems against photodynamic damage by quenching singlet oxygen with a high efficiency.
MedLine Citation:
PMID:  12945577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report concerns physiological function of mycosporine-like amino acids (MAA) as an active defense against the photooxidative effects of sunlight in marine organisms. Mycosporine glycine (MG) is a representative member of MAA family and was found to effectively suppress various detrimental effects of the Type-II photosensitization in biological systems, such as inactivation of mitochondrial electron transport, lipid peroxidation of microsomes, hemolysis of erythrocytes and growth inhibition of Escherichia coli. The presence of MG in solutions of eosin Y or methylene blue resulted in a marked decrease in the level of singlet oxygen (1O2) produced by the sensitizers under illumination. The rate constant of 1O2 quenching by MG was determined to be 5.6 x 10(7) M(-1) s(-1) by the time-resolved 1O2 luminescence decay method, which is higher than, or at least comparable to, the values for 1O2 reaction of well-known quenchers such as 1,4-diazabicyclo[2,2,2]octane and furfuryl alcohol. The results suggest that MG probably together with some other active MAA may play an important role in protecting marine organisms against sunlight damage by eliminating 1O2 generated from certain endogenous photosensitizers.
Authors:
Hwa-Jin Suh; Hyun-Woo Lee; Jin Jung
Related Documents :
24324947 - Vkorc1 and cyp2c9 genotype variations in relation to warfarin dosing in korean stroke p...
12008097 - Low dose ethanol potentiates indomethacin induced inhibition of wound re-epithelializat...
7602467 - Protection by almagate of ethanol-induced gastric mucosal damage in rats.
17220547 - Effect of combined administration of ethanol and tiagabine on rabbit eeg.
3977147 - Safe and effective iv regional anesthesia for use in the emergency department.
12707157 - Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal he...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  78     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-29     Completed Date:  2003-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-13     Citation Subset:  IM    
Affiliation:
School of Agricultural Biotechnology, Seoul National University, Suwon, South Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aplysia / radiation effects
Escherichia coli / growth & development,  radiation effects*
Glycine / pharmacology*
Hemolysis / radiation effects
Humans
Kinetics
Phytoplankton / radiation effects
Sea Cucumbers / radiation effects
Seawater
Singlet Oxygen*
Submitochondrial Particles / radiation effects
Sunscreening Agents / pharmacology*
Urochordata / radiation effects
Chemical
Reg. No./Substance:
0/Sunscreening Agents; 17778-80-2/Singlet Oxygen; 56-40-6/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intrinsic fluorescence polarization of amniotic fluid: evaluation of human fetal lung maturity.
Next Document:  Inter- and intraspecific variation in excited-state triplet energy transfer rates in reaction center...