| Mycoplasma pneumoniae central nervous system infections. | |
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MedLine Citation:
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PMID: 16914976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Mycoplasma pneumoniae is associated with a wide range of central nervous system diseases, most importantly with childhood encephalitis. This review summarizes and discusses recent findings in the field of M. pneumoniae central nervous system infections in context with previously published findings, with reference to clinical spectrum, pathogenesis, diagnosis, and treatment. RECENT FINDINGS: Further insight into the pathogenesis has been provided by studies on cytokine production and autoantibody formation. Some new manifestations have been described (e.g. Kluver-Bucy syndrome, intracranial hypertension). Anecdotal descriptions on the association of M. pneumoniae with uncommon neurologic diseases remain to be confirmed by additional reports, however, especially when aetiologic diagnosis relied exclusively on serology. New knowledge on treatment options targeting the immune system has been provided by isolated reports. Recent diagnostic advances refer to general methods (polymerase chain reaction, serology), without specific reference to neurologic disease. SUMMARY: M. pneumoniae must be considered as causative agent of various neurologic diseases. The recent literature shows, however, that the clinical spectrum of M. pneumoniae central nervous system disease is still not well defined. In addition, the main future challenges are the investigation of the pathogenesis of M. pneumoniae central nervous system disease and the establishment of therapeutic approaches. |
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Authors:
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Florian Daxboeck |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in neurology Volume: 19 ISSN: 1350-7540 ISO Abbreviation: Curr. Opin. Neurol. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-17 Completed Date: 2006-09-20 Revised Date: 2013-01-18 |
Medline Journal Info:
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Nlm Unique ID: 9319162 Medline TA: Curr Opin Neurol Country: England |
Other Details:
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Languages: eng Pagination: 374-8 Citation Subset: IM |
Affiliation:
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Clinical Institute for Hygiene and Medical Microbiology, Division of Hospital Hygiene, Medical University Vienna, Vienna General Hospital, Vienna, Austria. florian.daxboeck@meduniwien.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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therapeutic use Central Nervous System Infections / diagnosis, microbiology, pathology, therapy* Humans Mycoplasma Infections / diagnosis, microbiology, pathology, therapy* Mycoplasma pneumoniae* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
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