Document Detail

Mycoplasma pneumoniae causing nervous system lesion and SIADH in the absence of pneumonia.
MedLine Citation:
PMID:  15003304     Owner:  NLM     Status:  MEDLINE    
A patient was admitted for fever and acute respiratory failure (ARF), rapidly progressive tetraparesis, delirium, behavioral abnormalities, and diplopia. Leukocytosis and a rise in C-reactive protein were present. A syndrome of inappropriate anti-diuretic hormone secretion (SIADH) was also diagnosed. Lumbar puncture yielded colorless CFS with mononuclear pleocytosis and protein rise. Electrodiagnosis revealed demyelinating polyneuropathy and axonal degeneration. Serum IgG and IgM for mycoplasma pneumoniae (MP) was consistent with acute infection, and erythromycin was started with rapid resolution of symptoms. Contrarily to most reports, an associated respiratory disease was not present and SIADH in association with MP has been reported only once, in a patient without direct central nervous system (CNS) involvement. Differential diagnosis and possible pathogenic mechanisms are discussed.
Miguel Coelho; Alfredo Leite; Artur Revés; Cristina Miranda; Isabel Serra; Teresa Brandão; Luísa Albuquerque; Paulo Freitas
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  106     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-08     Completed Date:  2004-05-20     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  129-31     Citation Subset:  IM    
Intensive Care Unit, Hospital Dr. Fernando Fonseca, IC 19, 2720 Amadora, Portugal.
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MeSH Terms
C-Reactive Protein / metabolism
Demyelinating Diseases / diagnosis*,  drug therapy,  immunology
Erythromycin / therapeutic use
Fever of Unknown Origin / etiology,  immunology
Guillain-Barre Syndrome / diagnosis*,  drug therapy,  immunology
Immunoglobulin G / blood
Immunoglobulin M / blood
Inappropriate ADH Syndrome / diagnosis*,  drug therapy,  immunology
Mycoplasma pneumoniae* / immunology
Neurologic Examination / drug effects
Pneumonia, Mycoplasma / diagnosis*,  drug therapy,  immunology
Quadriplegia / etiology,  immunology
Respiratory Insufficiency / etiology,  immunology
Retrograde Degeneration / diagnosis*,  drug therapy,  immunology
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M; 114-07-8/Erythromycin; 9007-41-4/C-Reactive Protein

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