Document Detail


Mycoplanecins, novel antimycobacterial antibiotics from Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov. III. Structural determination of mycoplanecin A.
MedLine Citation:
PMID:  6630067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The structure of mycoplanecin A was determined by the analysis of chemical degradation products and by mass and 1H and 13C NMR spectrometries. Mycoplanecin A is a new cyclic peptide antibiotic composed of mol each of alpha-ketobutyric acid, glycine, L-leucine, L-proline, L-2-amino-5-methylhexanoic acid, N-methyl-D-leucine, N-methyl-L-threonine, methyl-L-proline and ethyl-L-proline and two mol of N-methyl-L-valine. Among these components, ethyl-L-proline is reported for the first time as a component of natural products. A newly developed mass analysis has been introduced for the differentiation of alpha-amino acid and its N-methyl derivative.
Authors:
M Nakajima; A Torikata; H Tamaoki; T Haneishi; M Arai; T Kinoshita; H Kuwano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  36     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  967-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Actinomycetales / growth & development*
Amino Acid Sequence
Anti-Bacterial Agents*
Hydrolysis
Indicators and Reagents
Magnetic Resonance Spectroscopy
Mass Spectrometry
Peptides / isolation & purification
Protein Conformation
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Indicators and Reagents; 0/Peptides; 72993-51-2/mycoplanecin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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