| Mycophenolic acid as a latent agonist of PPARgamma. | |
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MedLine Citation:
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PMID: 17618115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor gamma (PPARgamma). |
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Authors:
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Makoto Ubukata; Hitomi Takamori; Misaki Ohashi; Shinya Mitsuhashi; Kaoru Yamashita; Tomohisa Asada; Noriyuki Nakajima; Nobuyasu Matsuura; Mie Tsuruga; Keiko Taki; Junji Magae |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-26 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 17 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-07 Completed Date: 2007-11-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 4767-70 Citation Subset: IM |
Affiliation:
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Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Kita-9, Nishi-9, Sapporo, Japan. m-ub@for.agr.hokudai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3T3-L1 Cells Animals Cell Differentiation Cell Line, Tumor Chemistry, Pharmaceutical / methods Dose-Response Relationship, Drug Drug Design Humans Ligands Mice Models, Chemical Mycophenolic Acid / pharmacology* PPAR gamma / agonists*, metabolism* Structure-Activity Relationship Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/PPAR gamma; 24280-93-1/Mycophenolic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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