| Mycophenolate mofetil treatment in children and adolescents with lupus. | |
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MedLine Citation:
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PMID: 20810399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Safety and efficacy data are presented on the use of mycophenolate mofetil (MMF) in 26 children and adolescents with lupus. Data include therapy before and 12 months after starting MMF. 18 of 26 patients had biopsy-proved lupus nephritis. Group 1 were commenced on MMF induction and/or maintenance therapy (n=14), group 2 converted from azathioprine because of inadequate disease control (n=12). 73% of all (10 (71%) group 1 and 10 (83%) group 2) patients experienced a significant improvement in British Isles Lupus Assessment Group score (from median 9.0 to 3.0). Children with hypocomplementaemia increased their C3 significantly in both groups (0.53-1.15 for group 1 and 0.63-1.2 g/l for group 2, p=0.001), and C4 level only in group 1 (0.08-0.17, p=0.01). Renal function and albuminuria improved in those with active nephritis (p≤0.01). Significant improvements were seen in both groups in haemoglobin, erythrocyte sedimentation rate and lymphocyte counts. Prednisolone dose was weaned in both groups, p<0.05. Side-effects were seen in four patients, but none was judged to be severe enough to discontinue treatment. MMF treatment in this cohort of children with lupus seemed to be safe, well tolerated and effective. |
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Authors:
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Ina Kazyra; Clarissa Pilkington; Stephen D Marks; Kjell Tullus |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2010-08-31 |
Journal Detail:
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Title: Archives of disease in childhood Volume: 95 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-26 Completed Date: 2010-12-28 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: England |
Other Details:
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Languages: eng Pagination: 1059-61 Citation Subset: AIM; IM |
Affiliation:
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Department of Paediatrics, Belarus State Medical University, Minsk, Belarus. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Complement C3 / metabolism Complement C4 / metabolism Drug Administration Schedule Drug Therapy, Combination Female Glucocorticoids / administration & dosage Humans Immunosuppressive Agents / adverse effects, therapeutic use* Lupus Erythematosus, Systemic / drug therapy*, immunology Lupus Nephritis / drug therapy Male Mycophenolic Acid / adverse effects, analogs & derivatives*, therapeutic use Prednisolone / administration & dosage Retrospective Studies Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 0/Complement C4; 0/Glucocorticoids; 0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 50-24-8/Prednisolone; 9242ECW6R0/mycophenolate mofetil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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