| Mycophenolate mofetil for the treatment of acute and chronic GVHD in bone marrow transplant patients. | |
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MedLine Citation:
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PMID: 9678797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy and safety of mycophenolate mofetil (MMF) in combination with CsA and prednisolone for the treatment of acute and chronic GVHD (aGVHD and cGVHD, respectively) after BMT and PBSCT from HLA-mismatched and -matched donors was evaluated in an open single center trial. Twenty-four patients, 17-48 years of age, with acute (n = 17) and chronic GVHD (n = 7) were treated with 2 g MMF daily in addition to CsA and prednisolone. Overall grade improvement of aGVHD was found in 11 of 17 (65%) patients treated with MMF. MMF therapy in the treatment of cGVHD led to moderate improvement in three of six patients with limited cGVHD. The most common adverse hematologic events of MMF were leukopenia (n = 6), anemia (n = 4) and thrombocytopenia (n = 3). Hematological adverse events were not severe and did not require the discontinuation of MMF. In this preliminary study, we have shown that MMF can be used safely for the treatment of aGVHD. In addition, the MMF therapy resulted in significant dose reduction of prednisolone for the treatment of GVHD. |
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Authors:
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N Basara; W I Blau; E Römer; M Rudolphi; M Bischoff; D Kirsten; H Sanchez; S Günzelmann; A A Fauser |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bone marrow transplantation Volume: 22 ISSN: 0268-3369 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-09-15 Completed Date: 1998-09-15 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 61-5 Citation Subset: IM |
Affiliation:
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Clinic for Bone Marrow Transplantation and Hematology/Oncology, Idar-Oberstein, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Anemia / chemically induced Bone Marrow Transplantation* Chronic Disease Cyclosporine / adverse effects, therapeutic use Female Graft vs Host Disease / drug therapy*, prevention & control Humans Immunosuppressive Agents / adverse effects, therapeutic use* Leukopenia / chemically induced Male Middle Aged Mycophenolic Acid / adverse effects, analogs & derivatives*, therapeutic use Prednisolone / adverse effects, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 50-24-8/Prednisolone; 59865-13-3/Cyclosporine; 9242ECW6R0/mycophenolate mofetil |
| Comments/Corrections | |
Comment In:
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Bone Marrow Transplant. 2000 Dec;26(12):1362-3
[PMID:
11223981
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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