Document Detail


Mycophenolate mofetil prevents high-fat diet-induced hypertension and renal glomerular injury in Dahl SS rats.
MedLine Citation:
PMID:  24400139     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
We designed experiments to test the hypothesis that Dahl salt-sensitive (SS) rats are sensitive to high-fat diet (HFD)-induced hypertension and renal injury via an inflammatory mechanism. Twelve-week-old Dahl SS rats were maintained on a normal diet (ND; 14% fat), HFD (59% fat), or HFD supplemented with the lymphocyte immunosuppressive agent, mycophenolate mofetil (HFD + MMF; 30 mg/kg/day orally in diet), for a period of 4 weeks. Mean arterial pressure (MAP), metabolic parameters, T lymphocyte (CD3(+)) localization, and renal structural damage were assessed during the studies. Four weeks of HFD significantly elevated MAP and visceral adiposity without changing circulating levels of lipids or adipokines. Immunohistochemical analysis demonstrated that SS rats on HFD had significantly greater numbers of CD3(+) cells in renal glomerular and medullary areas compared to ND SS rats. Additionally, HFD led to increased glomerular injury, but did not alter renal medullary injury. Chronic MMF treatment in HFD-fed Dahl SS rats reduced MAP, visceral adiposity, infiltration of CD3(+) cells in the glomerulus, as well as glomerular injury. However, MMF treatment did not alter HFD-induced infiltration of CD3(+) cells in the renal medulla. In conclusion, Dahl SS rats are sensitized to HFD-induced hypertension and renal glomerular injury via infiltration of T lymphocytes.
Authors:
Frank T Spradley; Carmen De Miguel; Janet Hobbs; David M Pollock; Jennifer S Pollock
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Publication Detail:
Type:  Journal Article     Date:  2013-11-05
Journal Detail:
Title:  Physiological reports     Volume:  1     ISSN:  2051-817X     ISO Abbreviation:  Physiol Rep     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2014-01-08     Completed Date:  2014-01-08     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101607800     Medline TA:  Physiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e00137     Citation Subset:  -    
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
P01 HL069999/HL/NHLBI NIH HHS; R01 HL060653/HL/NHLBI NIH HHS

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