| Mycophenolate mofetil in the treatment of ocular inflammation in ANCA-associated vasculitis. | |
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MedLine Citation:
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PMID: 18321200 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of this study was to describe the use of mycophenolate mofetil (MMF) in the treatment of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis with ocular involvement. METHODS: A retrospective review was performed. Ocular and systemic manifestations, history of previous immunosuppressive drug therapy, concurrent therapy with MMF, response to treatment, side effects related to the use of MMF, and follow-up period were recorded. RESULTS: Nine (9) eyes of 5 patients were evaluated. Ocular involvement included scleritis, choroidal and orbital granuloma, multifocal choroiditis, intermediate uveitis, and lacrimal gland involvement. Mycophenolate was started at 2 g daily. Mean follow-up after the initiation of MMF was 36 months. Mean prednisolone dose at onset of treatment with MMF was 27 mg daily and was reduced to 7 mg daily as disease control was achieved. Visual acuity was maintained or improved in all eyes, apart from 1 eye, which developed cataract formation. One (1) patient required a reduction in the dose of mycophenolate owing to diarrhea. CONCLUSIONS: Our study suggests that mycophenolate mofetil may be a safe, effective therapeutic modality for ocular inflammation associated with ANCA-associated vasculitis. |
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Authors:
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F Nilüfer Yalçindağ; Radgonde Amer; John V Forrester |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Volume: 24 ISSN: 1080-7683 ISO Abbreviation: J Ocul Pharmacol Ther Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-24 Completed Date: 2008-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9511091 Medline TA: J Ocul Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 249-54 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Aberdeen Medical School, Aberdeen, UK. yalcinda@medicine.ankara.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents / therapeutic use Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, adverse effects, therapeutic use* Antibodies, Antineutrophil Cytoplasmic / immunology Cataract / etiology Diarrhea / chemically induced Eye Diseases / drug therapy*, etiology Female Follow-Up Studies Humans Middle Aged Mycophenolic Acid / administration & dosage, adverse effects, analogs & derivatives*, therapeutic use Prednisolone / therapeutic use Retrospective Studies Vasculitis / drug therapy*, immunology, physiopathology Visual Acuity / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Antineutrophil Cytoplasmic; 128794-94-5/mycophenolate mofetil; 24280-93-1/Mycophenolic Acid; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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