Document Detail


Mycophenolate mofetil in pregnancy after renal transplantation: a case of major fetal malformations.
MedLine Citation:
PMID:  15121619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Mycophenolate mofetil has teratogenic properties in rats and rabbits. Previous human studies have reported an increased rate of fetal losses with its use. We report a case of major fetal malformations due to mycophenolate mofetil.
CASE: The patient was treated with mycophenolate mofetil before conception and during the first trimester of pregnancy. The fetus had multiple malformations, specifically, facial dysmorphology and midline anomalies, including agenesis of the corpus callosum.
CONCLUSION: This case of fetal malformation attributable to mycophenolate mofetil must be taken into consideration when considering pregnancy in an organ-transplant recipient.
Authors:
Camille Le Ray; Aurore Coulomb; Elisabeth Elefant; Rene Frydman; François Audibert
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  103     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-06-04     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1091-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Hôpital Antoine Béclère, Clamart, France.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / pathology*
Adult
Animals
Female
Fetus / pathology
Humans
Immunosuppressive Agents / adverse effects*,  therapeutic use
Kidney Transplantation*
Mycophenolic Acid / adverse effects*,  analogs & derivatives*,  therapeutic use
Pregnancy
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 9242ECW6R0/mycophenolate mofetil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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