| Mycophenolate mofetil in pregnancy after renal transplantation: a case of major fetal malformations. | |
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MedLine Citation:
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PMID: 15121619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Mycophenolate mofetil has teratogenic properties in rats and rabbits. Previous human studies have reported an increased rate of fetal losses with its use. We report a case of major fetal malformations due to mycophenolate mofetil. CASE: The patient was treated with mycophenolate mofetil before conception and during the first trimester of pregnancy. The fetus had multiple malformations, specifically, facial dysmorphology and midline anomalies, including agenesis of the corpus callosum. CONCLUSION: This case of fetal malformation attributable to mycophenolate mofetil must be taken into consideration when considering pregnancy in an organ-transplant recipient. |
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Authors:
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Camille Le Ray; Aurore Coulomb; Elisabeth Elefant; Rene Frydman; François Audibert |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 103 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-03 Completed Date: 2004-06-04 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1091-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Hôpital Antoine Béclère, Clamart, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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pathology* Adult Animals Female Fetus / pathology Humans Immunosuppressive Agents / adverse effects*, therapeutic use Kidney Transplantation* Mycophenolic Acid / adverse effects*, analogs & derivatives*, therapeutic use Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 128794-94-5/mycophenolate mofetil; 24280-93-1/Mycophenolic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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