Document Detail


Mycophenolate mofetil in neuropsychiatric systemic lupus erythematosus.
MedLine Citation:
PMID:  16129929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuropsychiatric abnormalities frequently occur in patients with systemic lupus erythematosus, affecting as many as 14-75% of people with this disease. High-dose steroid with or without anticoagulation is the mainstay of treatment in neuropsychiatric systemic lupus erythematosus (NPSLE). Use of mycophenolate as a steroid sparing drug may be a potential alternative agent in the therapy of NPLE, but lack of randomized trials and cost prohibit its widespread use. Its safety profile is higher than that of cyclophosphamide and azathioprine. We report a successfully treated case of neuropsychiatric systemic lupus erythematosus, presenting as psychosis, whose long-term remission was maintained on treatment with mycophenolate mofetil.
Authors:
J Jose; B K Paulose; Z Vasuki; D Danda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Indian journal of medical sciences     Volume:  59     ISSN:  0019-5359     ISO Abbreviation:  Indian J Med Sci     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-30     Completed Date:  2005-11-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0373023     Medline TA:  Indian J Med Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  353-6     Citation Subset:  IM    
Affiliation:
Department of General Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Immunosuppressive Agents / therapeutic use*
Lupus Vasculitis, Central Nervous System / drug therapy*
Mycophenolic Acid / analogs & derivatives*,  therapeutic use
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 9242ECW6R0/mycophenolate mofetil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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