| Mycophenolate mofetil as therapy for pyoderma gangrenosum. | |
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MedLine Citation:
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PMID: 19620559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pyoderma gangrenosum is an ulcerative condition that may be associated with inflammatory bowel disease or inflammatory arthritis. In addition to local wound care, management often includes the use of systemic corticosteroids or systemically administered immunomodulatory agents. OBSERVATIONS: We retrospectively analyzed 7 patients with pyoderma gangrenosum who were treated with mycophenolate mofetil. Patients were included if they had a diagnosis of pyoderma gangrenosum and were treated with mycophenolate mofetil for at least 2 uninterrupted months. Improvement was based on reduction in lesion size or decrease in concomitant therapy. Overall, 6 of 7 patients had some reduction in ulcer size while receiving mycophenolate mofetil therapy, and 4 of 7 completely healed. However, responsiveness was inadequate in 3 patients. Two discontinued mycophenolate mofetil for alternate therapy, and the third required the addition of dapsone and infliximab for complete healing. The only adverse event observed in our analysis attributed to mycophenolate mofetil therapy was transient anemia. CONCLUSIONS: Mycophenolate mofetil may be beneficial as an immunomodulatory agent in selected patients with pyoderma gangrenosum. Further controlled trials are warranted to define its place among the therapeutic options for this rare disease. |
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Authors:
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Philip A Eaton; Jeffrey P Callen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of dermatology Volume: 145 ISSN: 1538-3652 ISO Abbreviation: Arch Dermatol Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-21 Completed Date: 2009-08-06 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 781-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Louisville, KY 40202, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Female Humans Immunosuppressive Agents / therapeutic use* Male Middle Aged Mycophenolic Acid / analogs & derivatives*, therapeutic use Pyoderma Gangrenosum / drug therapy* Retrospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 9242ECW6R0/mycophenolate mofetil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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