Document Detail

Mycophenolate mofetil as therapy for pyoderma gangrenosum.
MedLine Citation:
PMID:  19620559     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pyoderma gangrenosum is an ulcerative condition that may be associated with inflammatory bowel disease or inflammatory arthritis. In addition to local wound care, management often includes the use of systemic corticosteroids or systemically administered immunomodulatory agents.
OBSERVATIONS: We retrospectively analyzed 7 patients with pyoderma gangrenosum who were treated with mycophenolate mofetil. Patients were included if they had a diagnosis of pyoderma gangrenosum and were treated with mycophenolate mofetil for at least 2 uninterrupted months. Improvement was based on reduction in lesion size or decrease in concomitant therapy. Overall, 6 of 7 patients had some reduction in ulcer size while receiving mycophenolate mofetil therapy, and 4 of 7 completely healed. However, responsiveness was inadequate in 3 patients. Two discontinued mycophenolate mofetil for alternate therapy, and the third required the addition of dapsone and infliximab for complete healing. The only adverse event observed in our analysis attributed to mycophenolate mofetil therapy was transient anemia.
CONCLUSIONS: Mycophenolate mofetil may be beneficial as an immunomodulatory agent in selected patients with pyoderma gangrenosum. Further controlled trials are warranted to define its place among the therapeutic options for this rare disease.
Philip A Eaton; Jeffrey P Callen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  145     ISSN:  1538-3652     ISO Abbreviation:  Arch Dermatol     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-08-06     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  781-5     Citation Subset:  AIM; IM    
Department of Medicine, University of Louisville, KY 40202, USA.
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MeSH Terms
Immunosuppressive Agents / therapeutic use*
Middle Aged
Mycophenolic Acid / analogs & derivatives*,  therapeutic use
Pyoderma Gangrenosum / drug therapy*
Retrospective Studies
Young Adult
Reg. No./Substance:
0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 9242ECW6R0/mycophenolate mofetil

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